Can delta neutrophil index values predict the success of periodontal treatment in patients with periodontitis?
Delta neutrophil index
Immature granulocytes
Non-surgical periodontal therapy
Periodontitis
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
09 Jan 2024
09 Jan 2024
Historique:
received:
30
06
2023
accepted:
23
12
2023
medline:
10
1
2024
pubmed:
10
1
2024
entrez:
9
1
2024
Statut:
epublish
Résumé
The aim of this study was to evaluate the effect of delta neutrophil index (DNI) on non-surgical periodontal therapy (NSPT), whose role has been documented in the pathogenesis and follow-up of periodontal disease. The study included 35 patients with stage 3, grade A periodontitis (test group) and 35 patients without periodontal disease (control group). Initially, periodontal parameters were recorded and blood samples were taken from all patients. For patients with periodontitis, periodontal parameter measurements and blood sample analyses were repeated 3 months after NSPT. After NSPT, DNI, CRP (C-reactive protein), neutrophil count, WBC (white blood cell), and neutrophil-lymphocyte ratio (NLR) values decreased in the test group, but did not reach a statistically significant level (p > 0.05). When the inflammatory variables were examined, significantly higher CRP, IG (immature granulocytes), DNI, neutrophil count, and WBC were observed in the test group compared to the control group (p < 0.05). In the test group, periodontal parameters were lower 3 months after NSPT than at baseline (p < 0.05). Consistent with previous findings in the literature, the patients with periodontitis were determined to have higher levels of DNI, CRP, neutrophils, and WBC, compared to the individuals without periodontitis. Although a decrease was seen in DNI after NSPT, this was not at a significant level. DNI is a guide in the evaluation of inflammation at the onset of periodontal disease, but studies with a larger number of cases are needed to use these parameters in the evaluation of treatment success. This study was retrospectively registered on December 27, 2022, with the number NCT05666622 at http://www. gov .
Identifiants
pubmed: 38195732
doi: 10.1007/s00784-023-05478-1
pii: 10.1007/s00784-023-05478-1
doi:
Banques de données
ClinicalTrials.gov
['NCT05666622']
Types de publication
Journal Article
Langues
eng
Pagination
82Informations de copyright
© 2024. The Author(s).
Références
Papapanou PN, Sanz M, Buduneli N et al (2018) Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol Suppl 1:173–182
Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol 89(Suppl 1):S159–S172
pubmed: 29926952
Herrera D, Sanz M, Kebschull M et al (2022) EFP workshop participants and methodological consultant. Treatment of stage IV periodontitis: the EFP S3 level clinical practice guideline. J Clin Periodontol Suppl 24:4–71
doi: 10.1111/jcpe.13639
Hajishengallis G, Chavakis T (2021) Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol 21(7):426–440
doi: 10.1038/s41577-020-00488-6
pubmed: 33510490
pmcid: 7841384
Ustaoglu G, Erdal E, İnanır M (2020) Does periodontitis affect mean platelet volume (MPV) and plateletcrit (PCT) levels in healthy adults? Rev Assoc Med Bras 66(2):133–138
doi: 10.1590/1806-9282.66.2.133
pubmed: 32428146
Roberts FA (2000) Darveau RP (2015) Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 69(1):18–27
doi: 10.1111/prd.12087
Acharya AB, Shetty IP, Jain S et al (2015) Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in chronic periodontitis before and after nonsurgical therapy. J Indian Soc Periodontol 23(5):419–423
doi: 10.4103/jisp.jisp_622_18
Valiyaveetil Karattil L, Joseph RS, Ambooken M, Mathew JJ (2022) Evaluation of serum concentrations of hs-CRP and Hb in varying severities of chronic periodontitis. Biomarkers 27(3):258–563
doi: 10.1080/1354750X.2022.2032349
pubmed: 35060836
Glurich I, Grossi S, Albini B et al (2002) Systemic inflammation in cardiovascular and periodontal disease: comparative study. Clin Diagn Lab Immunol 9(2):425–432
pubmed: 11874889
pmcid: 119918
Brum RS, Duarte PM, Canto GDL et al (2020) Biomarkers in biological fluids in adults with periodontitis and/or obesity: a meta-analysis. J Indian Soc Periodontol 24(3):191–215
doi: 10.4103/jisp.jisp_512_19
pubmed: 32773969
pmcid: 7307467
Papapanagiotou D, Nicu EA, Bizzarro S et al (2009) Periodontitis is associated with platelet activation. Atherosclerosis 202(2):605–611
doi: 10.1016/j.atherosclerosis.2008.05.035
pubmed: 18617175
Loos BG, Craandijk J, Hoek FJ, Dillen PMWV, Van Der Velden U (2007) Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 71(10):1528–1534
doi: 10.1902/jop.2000.71.10.1528
Kratz A, Maloum K, O’Malley C, Zini G, Rocco V, Zelmanovic D, Kling G (2006) Enumeration of nucleated red blood cells with the ADVIA 2120 hematology system: an international multicenter clinical trial. Lab Hematol 12(2):63–70
doi: 10.1532/LH96.06010
pubmed: 16751132
Yoon NB, Son C, Um SJ (2013) Role of the neutrophil-lymphocyte count ratio in the differential diagnosis between pulmonary tuberculosis and bacterial community-acquired pneumonia. Ann Lab Med 33(2):105–110
doi: 10.3343/alm.2013.33.2.105
pubmed: 23482854
pmcid: 3589634
Bermejo-Martín JF, Tamayo E, Ruiz G et al (2014) Circulating neutrophil counts and mortality in septic shock. Crit Care 18(1):407
doi: 10.1186/cc13728
pubmed: 24524810
pmcid: 4057453
Son S, An HG, Park JS et al (2021) Delta neutrophil index levels can be a good indicator to predict patients with chronic rhinosinusitis who need surgery. Ear Nose Throat J 24:1455613211058491
Kang HS, Cha YS, Park KH, Hwang SO (2017) Delta neutrophil index as a promising prognostic marker of emergent surgical intervention for acute diverticulitis in the emergency department. PLoS ONE 12(11):e0187629
doi: 10.1371/journal.pone.0187629
pubmed: 29091955
pmcid: 5665552
Bozan MB, Mehmet F, Boran ÖF, Güler Ö, Azak Bozan A (2022) Are the immature granulocyte count and percentage important in continue medical treatment in acute appendicitis? A prospective, randomized, and controlled study. Ulus Travma Acil Cerrahi Derg 28(7):979–987
pubmed: 35775679
Barut O, Demirkol MK, Bilecan EB, Sahinkanat T, Resim S (2020) The delta neutrophil index is an early predictive marker of acute pyelonephritis in patients with ureteral stone. J Coll Physicians Surg Pak 30(11):1149–1154
doi: 10.29271/jcpsp.2020.11.1149
pubmed: 33222730
Kim TY, Kim SJ, Kim YS et al (2019) Delta neutrophil index as an early predictive marker of severe acute pancreatitis in the emergency department. United European Gastroenterol J 7(4):488–495
doi: 10.1177/2050640619838359
pubmed: 31065366
pmcid: 6488799
Çetin Özdemir E, Bilen E, Yazar FM (2022) Can the delta neutrophil ındex be used as a preliminary biomarker ın the evaluation of periodontal disease: a pilot study. J Appl Oral Sci 30:e20210555
doi: 10.1590/1678-7757-2021-0555
pubmed: 35319605
pmcid: 8963392
Von Elm E, Altman DG, Egger M et al (2014) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Int J Surg 12(12):1495–1499
doi: 10.1016/j.ijsu.2014.07.013
Chapple IL, Mealey BL, Van Dyke TE et al (2018) Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 89(Suppl 1):S74–S84
pubmed: 29926944
Silness J, Löe H (1964) Periodontal disease in pregnancy II Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 22(1):121–135
doi: 10.3109/00016356408993968
pubmed: 14158464
Lachat MF, Solnik AL, Nana AD, Citron TL (2011) Periodontal disease in pregnancy: review of the evidence and prevention strategies. J Perinat Neonatal Nurs 25(4):312–319
doi: 10.1097/JPN.0b013e31821072e4
pubmed: 22071614
Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25(4):229–235
pubmed: 1058834
Bozan MB, Mehmet F, Kale IT, Yüzbaşıoğlu MF, Boran ÖF, Azak Bozan A (2021) Delta neutrophil index and neutrophil-to-lymphocyte ratio in the differentiation of thyroid malignancy and nodular goiter. World J Surg 45(2):507–514
doi: 10.1007/s00268-020-05822-6
pubmed: 33067685
Loos BG (2005) Systemic markers of inflammation in periodontitis. J Periodontol 76(11 Suppl):2106–2115
doi: 10.1902/jop.2005.76.11-S.2106
pubmed: 16277583
Esteves-Lima R-P, Reis C-S, Santirocchi-Júnior F, Abreu L-G, Costa F-O (2020) Association between periodontitis and serum c-reactive protein levels. J Clin Exp Dent 12(9):e838–e843
doi: 10.4317/jced.57041
pubmed: 32994872
pmcid: 7511054
Paraskevas S, Huizinga JD, Loos BG (2008) A systematic review and meta-analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol 35(4):277–290
doi: 10.1111/j.1600-051X.2007.01173.x
pubmed: 18294231
Mysak J, Podzimek S, Vasakova J, Mazanek J, Vinsu A, Duskova J (2017) C-reactive protein in patients with aggressive periodontitis. J Dent Sci 12(4):368–374
doi: 10.1016/j.jds.2017.04.003
pubmed: 30895077
pmcid: 6395364
Lu R, Li W, Wang X, Shi D, Meng H (2021) Elevated neutrophil-to-lymphocyte ratio but not platelet-to-lymphocyte ratio is associated with generalized aggressive periodontitis in a Chinese population. J Periodontol 92(4):507–513
doi: 10.1002/JPER.20-0282
pubmed: 32909291
Doğan B, Fentoğlu Ö, Kırzıoğlu FY et al (2015) Lipoxin A4 and neutrophil/lymphocyte ratio: a possible indicator in achieved systemic risk factors for periodontitis. Med Sci Monit 21:2485–2493
doi: 10.12659/MSM.895115
pubmed: 26298769
pmcid: 4551304
Torrungruang K, Ongphiphadhanakul B, Jitpakdeebordin S, Sarujikumjornwatana S (2018) Mediation analysis of systemic inflammation on the association between periodontitis and glycaemic status. J Clin Periodontol 45(5):548–556
doi: 10.1111/jcpe.12884
pubmed: 29500831
Park H-J, Ha Y-J, Pyo J-Y, Park Y-B, Lee S-K, Lee S-W (2014) Delta neutrophil index as an early marker for differential diagnosis of adult-onset Still’s disease and sepsis. Yonsei Med J 55(3):753–759
doi: 10.3349/ymj.2014.55.3.753
pubmed: 24719144
pmcid: 3990089
Ahn JG, Choi SY, Kim DS, Kim KH (2014) Limitation of the delta neutrophil index for assessing bacteraemia in immunocompromised children. Clin Chim Acta 436:319–322
doi: 10.1016/j.cca.2014.06.020
pubmed: 24978822
Incir S, Calti HK, Palaoglu KE (2020) The role of immature granulocytes and inflammatory hemogram indices in the inflammation. Int J Med Biochem 3(3):125–130
Nahm CH, Choi JW, Lee J (2008) Delta neutrophil index in automated immature granulocyte counts for assessing disease severity of patients with sepsis. Ann Clin Lab Sci 38(3):241–246
pubmed: 18715852
Park S, Lee SJ, Shin B et al (2020) The association of delta neutrophil index with the prognosis of acute exacerbation of chronic obstructive pulmonary disease. BMC Pulm Med 20(1):47
doi: 10.1186/s12890-020-1083-4
pubmed: 32075629
pmcid: 7031980