Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects.
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
10 Jan 2024
10 Jan 2024
Historique:
received:
26
10
2023
accepted:
30
12
2023
medline:
10
1
2024
pubmed:
10
1
2024
entrez:
10
1
2024
Statut:
aheadofprint
Résumé
Isotretinoin is an effective treatment against acne vulgaris, but it also causes many side effects during and after the treatment. The relationship between the changes in the levels of plasma trace elements of patients with AV after 3 months of isotretinoin treatment and the side effects was investigated in the study. Plasma samples of 35 patients were collected before and after isotretinoin treatment. Samples were analyzed by Inductively Coupled Plasma-Mass Spectrometer. After treatment, the levels of phosphorus, magnesium, and zinc in plasma increased statistically, while the level of potassium decreased (p < 0.05). The treatment had differing effects on zinc levels based on the gender of the individuals. With treatment, the levels of zinc in the plasma of men showed a greater increase compared to women (p = 7.3e-04). Additionally, the correlation matrix analysis revealed a strong correlation (R > 0.8) between magnesium and calcium. According to the study results, the change in phosphorus and potassium levels shows that isotretinoin affects kidney functions. The results suggest that phosphorus, potassium, magnesium, and zinc are associated with fatigue, dry skin and chapped lips, hair loss, and sebum secretion, respectively. Consequently, the study emphasizes the need for a comprehensive pre-treatment assessment, including monitoring of liver and kidney function as well as the levels of phosphorus and potassium in patients.
Identifiants
pubmed: 38197903
doi: 10.1007/s12011-023-04053-9
pii: 10.1007/s12011-023-04053-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Research Fund of Erzincan Binali Yıldırım University
ID : TSA-2021-793
Organisme : Research Fund of Erzincan Binali Yıldırım University
ID : TSA-2021-793
Organisme : Research Fund of Erzincan Binali Yıldırım University
ID : TSA-2021-793
Informations de copyright
© 2024. The Author(s).
Références
Ibrahim MA, Mohammed SA, Elhabak DM (2021) Role of KLF2: new insight in inflammatory acne pathogenesis. J Cosmet Dermatol 20:964–970. https://doi.org/10.1111/JOCD.13595
doi: 10.1111/JOCD.13595
pubmed: 32623820
Bagatin E, De FTHP, Rivitti Machado MC et al (2019) Adult female acne: a guide to clinical practice. An Bras Dermatol 94:62–75. https://doi.org/10.1590/ABD1806-4841.20198203
doi: 10.1590/ABD1806-4841.20198203
pubmed: 30726466
pmcid: 6360964
Chitturi R, Baddam VR, Prasad L et al (2015) A review on role of essential trace elements in health and disease. J Dr NTR Univ Heal Sci 4:75. https://doi.org/10.4103/2277-8632.158577
doi: 10.4103/2277-8632.158577
Shayganfard M (2021) Are essential trace elements effective in modulation of mental disorders? Update and perspectives. Biol Trace Elem Res 2021 2003 200:1032–1059. https://doi.org/10.1007/S12011-021-02733-Y
Bilgiç Ö, Altinyazar HC, Sivrikaya A, Ünlü A (2014) The relationship between erythrocyte zinc levels and isotretinoin use in acne vulgaris patients. 34:303–306. https://doi.org/10.3109/15569527.2014.979426
Blasiak RC, Stamey CR, Burkhart CN et al (2013) High-dose isotretinoin treatment and the rate of retrial, relapse, and adverse effects in patients with acne vulgaris. JAMA Dermatol 149:1392–1398. https://doi.org/10.1001/JAMADERMATOL.2013.6746
doi: 10.1001/JAMADERMATOL.2013.6746
pubmed: 24173086
On SCJ, Zeichner J (2013) Isotretinoin updates. Dermatol Ther 26:377–389. https://doi.org/10.1111/DTH.12084
doi: 10.1111/DTH.12084
pubmed: 24099068
McElwee NE, Schumacher MC, Johnson SC et al (1991) An observational study of isotretinoin recipients treated for acne in a health maintenance organization. Arch Dermatol 127:341–346. https://doi.org/10.1001/ARCHDERM.1991.01680030061007
doi: 10.1001/ARCHDERM.1991.01680030061007
pubmed: 1825596
Ozuguz P, DogrukKacar S, Ekiz O et al (2014) Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol 33:99–102. https://doi.org/10.3109/15569527.2013.808656
doi: 10.3109/15569527.2013.808656
pubmed: 23826827
El-Dibany SA, Elhassi R (2019) Evalution serum zinc level in acne and correlation with severity acne vulgaris Benghazi-Libya. Int J Clin Dermatol Res 7:197–200. https://doi.org/10.19070/2332-2977-1900047
doi: 10.19070/2332-2977-1900047
Butool F, Mohammed A, Ali Syed P et al (2019) Role of serum zinc and copper levels in patients with acne vulgaris. J Orofac Res 8:71–75
Rostami Mogaddam M, Safavi Ardabili N, Maleki N, Soflaee M (2014) Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. Biomed Res Int 2014. https://doi.org/10.1155/2014/474108
Saleh B, Anbar Z, Sci AM-IJP, 2011 undefined (2011) Serum trace elements (zinc, copper and magnesium) status in Iraqi patients with acne vulgaris:(case-controlled study). iasj.net 20
Ghafarpour GH, Ebrahimi V, Aziz Jalali MH (2012) The association of zinc serum level with age, sex and disease severity in acne vulgaris patients. J Isfahan Med Sch 29:3008–3015
Rao PK, Bhat RM, Nandakishore B et al (2014) Safety and efficacy of low-dose isotretinoin in the treatment of moderate to severe acne vulgaris. Indian J Dermatol 59:316. https://doi.org/10.4103/0019-5154.131455
doi: 10.4103/0019-5154.131455
pubmed: 24891681
pmcid: 4037971
Cohen J (1992) A power primer. Psychol Bull 112:155–159. https://doi.org/10.1037//0033-2909.112.1.155
doi: 10.1037//0033-2909.112.1.155
pubmed: 19565683
Hegde ML, Shanmugavelu P, Vengamma B et al (2004) Serum trace element levels and the complexity of inter-element relations in patients with Parkinson’s disease. J Trace Elem Med Biol 18:163–171. https://doi.org/10.1016/J.JTEMB.2004.09.003
doi: 10.1016/J.JTEMB.2004.09.003
pubmed: 15646263
Chen X, Li Y, Zhang T et al (2018) Association of serum trace elements with schizophrenia and effects of antipsychotic treatment. Biol Trace Elem Res 181:22–30. https://doi.org/10.1007/S12011-017-1039-6/TABLES/6
doi: 10.1007/S12011-017-1039-6/TABLES/6
pubmed: 28470477
Bahareh F-H, Karimzadeh I (2020) Isotretinoin and the kidney: opportunities and threats. Clin Cosmet Investig Dermatol 13:485–494. https://doi.org/10.2147/CCID.S259048
doi: 10.2147/CCID.S259048
Kapetanovic I, Zivanovic D, Mijuskovic M, Minic S (2023) The unknown silent drug reaction in acne patients: rare case of isotretinoin-induced haematuria. Fam Pract. https://doi.org/10.1093/FAMPRA/CMAD043
doi: 10.1093/FAMPRA/CMAD043
pubmed: 37602648
Feinstein S, Becker-Cohen R, Rinat C, Frishberg Y (2006) Hyperphosphatemia is prevalent among children with nephrotic syndrome and normal renal function. Pediatr Nephrol 21:1406–1412. https://doi.org/10.1007/S00467-006-0195-2/FIGURES/3
doi: 10.1007/S00467-006-0195-2/FIGURES/3
pubmed: 16897004
Song Y, Ding L, An X et al (2023) Hypokalemia after rituximab administration in nephrotic syndrome: two case reports. BMC Nephrol 24:1–4. https://doi.org/10.1186/S12882-023-03079-4/FIGURES/2
doi: 10.1186/S12882-023-03079-4/FIGURES/2
Naffaa ME, Mustafa M, Azzam M et al (2015) Serum inorganic phosphorus levels predict 30-day mortality in patients with community acquired pneumonia. BMC Infect Dis 2015 151 15:1–10. https://doi.org/10.1186/S12879-015-1094-6
Arnold R, Pianta TJ, Pussell BA et al (2019) Potassium control in chronic kidney disease: implications for neuromuscular function. Intern Med J 49:817–825. https://doi.org/10.1111/IMJ.14114
doi: 10.1111/IMJ.14114
pubmed: 30230667
Vormann J (2003) Magnesium: nutrition and metabolism. Mol Aspects Med 24:27–37. https://doi.org/10.1016/S0098-2997(02)00089-4
doi: 10.1016/S0098-2997(02)00089-4
pubmed: 12537987
Skrok A, Bednarczuk T, Skwarek A et al (2015) The effect of parathyroid hormones on hair follicle physiology: implications for treatment of chemotherapy-induced alopecia. Skin Pharmacol Physiol 28:213–225. https://doi.org/10.1159/000375319
doi: 10.1159/000375319
pubmed: 25721772
Katikaneni R, Seymour AW, Gulati R et al (2015) Therapy for alopecia areata in mice by stimulating the hair cycle with parathyroid hormone agonists linked to a collagen-binding domain. J Investig Dermatology Symp Proc 17:13–15. https://doi.org/10.1038/JIDSYMP.2015.32
doi: 10.1038/JIDSYMP.2015.32
Gilbert R, Peto T, Lengyel I, Emri E (2019) Zinc nutrition and inflammation in the aging retina. Mol Nutr Food Res 63:1801049. https://doi.org/10.1002/MNFR.201801049
doi: 10.1002/MNFR.201801049
Abadie M Al, Sharara Z, Abadie M Al et al (2022) Possible relationship between poor skin disorders prognosis and serum zinc level: a narrative review. Dermatol Rep 14. https://doi.org/10.4081/DR.2022.9512
Gaber HAA, Abozied AA-H, Abd-Elkareem IM, El-Shazly YNY (2019) Serum zinc levels in patients with acne vulgaris and its relation to the severity of disease. Egypt J Hosp Med 75:2845–2848. https://doi.org/10.21608/EJHM.2019.33005
doi: 10.21608/EJHM.2019.33005
Awad SM, Morsy H, Sayed AA et al (2018) Oxidative stress and psychiatric morbidity in patients with facial acne. J Cosmet Dermatol 17:203–208. https://doi.org/10.1111/JOCD.12366
doi: 10.1111/JOCD.12366
pubmed: 28631890
Goodarzi A, Roohaninasab M, Atefi NS et al (2020) Determination of serum levels of zinc in acne vulgaris patients: a case control study. Iran J Dermatol 23:28–31. https://doi.org/10.22034/IJD.2020.108066
doi: 10.22034/IJD.2020.108066
Ikaraoha CI, Mbadiwe NC, Anyanwu CJ et al (2017) The role of blood lead, cadmium, zinc and copper in development and severity of acne vulgaris in a Nigerian population. Biol Trace Elem Res 176:251–257. https://doi.org/10.1007/S12011-016-0839-4/TABLES/6
doi: 10.1007/S12011-016-0839-4/TABLES/6
pubmed: 27600928
Kumar G, Group TP-, 2018 undefined (2018) Correlation of serum zinc levels with severity of acne vulgaris. researchgate.net. https://doi.org/10.14260/jemds/2018/127
Yee BE, Richards P, Sui JY, Marsch AF (2020) Serum zinc levels and efficacy of zinc treatment in acne vulgaris: a systematic review and meta-analysis. Dermatol Ther 33:e14252. https://doi.org/10.1111/DTH.14252
doi: 10.1111/DTH.14252
pubmed: 32860489