Distinct Metabolic Profiles of Ocular Hypertensives in Response to Hypoxia.
energy metabolism
glaucoma
hypoxia
metabolomics
normal-tension glaucoma
ocular hypertension
oxygen stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Dec 2023
22 Dec 2023
Historique:
received:
26
11
2023
revised:
20
12
2023
accepted:
20
12
2023
medline:
11
1
2024
pubmed:
11
1
2024
entrez:
11
1
2024
Statut:
epublish
Résumé
Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs). The main risk factor is elevated intraocular pressure (IOP), but the actual cause of the disease remains unknown. Emerging evidence indicates that metabolic dysfunction plays a central role. The aim of the current study was to determine and compare the effect of universal hypoxia on the metabolomic signature in plasma samples from healthy controls (
Identifiants
pubmed: 38203366
pii: ijms25010195
doi: 10.3390/ijms25010195
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Jørgen Bagenkop Nielsens Eye-Foundation
ID : 117138, 117139, and 119012
Organisme : Øjenforeningen
ID : 115774, 113846, and 114065
Organisme : Synoptikfonden
ID : 117140 and 118012