Continuous Direct Mechanocatalytic Suzuki-Miyaura Coupling via Twin-Screw Extrusion.
Extrusion, Suzuki-Miyaura, Mechanochemistry, Direct Meachanocatalysis, Sustainability
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
11 Jan 2024
11 Jan 2024
Historique:
revised:
11
01
2024
received:
06
12
2023
accepted:
11
01
2024
medline:
11
1
2024
pubmed:
11
1
2024
entrez:
11
1
2024
Statut:
aheadofprint
Résumé
This work establishes the first direct mechanocatalytic reaction protocol within an extruder, focusing on the Suzuki-Miyaura reaction. Through the coating of either the extruder screws or barrel with Pd, we executed the cross-coupling reaction without the reliance on molecular catalyst compounds or powders, and solvents continuously. We identified the influence and interplay of crucial reaction parameters such as temperature, mechanical energy input, residence time, rheology, and catalyst contact time and finally obtained 36% and 75% of the reaction product after one and four reactor passes respectively.
Identifiants
pubmed: 38206188
doi: 10.1002/chem.202304060
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202304060Informations de copyright
© 2024 Wiley-VCH GmbH.