MicroRNAs and Cardiovascular Disease Risk.
Arrhythmia
Biomarker
Cardiovascular disease
Coronary artery disease
Extracellular microRNA
Heart failure
MicroRNA
Journal
Current cardiology reports
ISSN: 1534-3170
Titre abrégé: Curr Cardiol Rep
Pays: United States
ID NLM: 100888969
Informations de publication
Date de publication:
02 2024
02 2024
Historique:
accepted:
10
12
2023
medline:
6
2
2024
pubmed:
11
1
2024
entrez:
11
1
2024
Statut:
ppublish
Résumé
MicroRNAs (miRNAs)-short, non-coding RNAs-play important roles in almost all aspects of cardiovascular biology, and changes in intracellular miRNA expression are indicative of cardiovascular disease development and progression. Extracellular miRNAs, which are easily measured in blood and can be reflective of changes in intracellular miRNA levels, have emerged as potential non-invasive biomarkers for disease. This review summarizes current knowledge regarding miRNAs as biomarkers for assessing cardiovascular disease risk and prognosis. Numerous studies over the last 10-15 years have identified associations between extracellular miRNA profiles and cardiovascular disease, supporting the potential use of extracellular miRNAs as biomarkers for risk stratification. However, clinical application of extracellular miRNA profiles has been hampered by poor reproducibility and inter-study variability that is due largely to methodological differences between studies. While recent studies indicate that circulating extracellular miRNAs are promising biomarkers for cardiovascular disease, evidence for clinical implementation is lacking. This highlights the need for larger, well-designed studies that use standardized methods for sample preparation, miRNA isolation, quantification, and normalization.
Identifiants
pubmed: 38206553
doi: 10.1007/s11886-023-02014-1
pii: 10.1007/s11886-023-02014-1
pmc: PMC10844442
doi:
Substances chimiques
MicroRNAs
0
Biomarkers
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-60Subventions
Organisme : NHGRI NIH HHS
ID : RM1 HG012334
Pays : United States
Organisme : NHGRI NIH HHS
ID : 1RM1HG012334
Pays : United States
Informations de copyright
© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
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