Herbal treatment of female urogenital atrophy: A retrospective cohort analysis.

Résumé

Urogenital atrophy and its sequelae, particularly genital dry-ness, urological problems, and pain on genital touching, are common medi-cal problems for menopausal women and women undergoing antihormonal cancer treatment. To meet the requirements for a nonhormonal local treatment, a compounded herbal preparation was developed as a vaginal ovule (Dioscorea comp. ovulum), and the efficacy and applicability of this herbal treatment were investigated. This was a retrospective chart review of patients' records. The study was approved by the Ethics Committee of the Canton of Zurich (project number BASEC 2016-01982). Between 2007 and 2011, patients with urogenital atrophy and related symptoms, who wanted to initiate herbal treatment, were asked for consent to be interviewed (4-point rating scale) and examined gynecologi-cally with photo documentation of their vaginal discharge. A total of 26 pa-tients met the enrollment criteria and consented to the procedure. Treat-ment: The first 8 weeks consisted of a daily application of low-dose Di-oscorea comp. ovulum followed by high-dose Dioscorea comp. ovule twice weekly for at least 3 months. A total of 23 patients completed the trial. Of the 19 patients in the subgroup with an atrophic vaginal maturation index (VMI), 16 achieved a eutrophic VMI. Four patients began therapy with hypotrophy. There was a 96% decrease in complaints (22/23). The genital dryness score decreased from 1.80 to 0.25 points, urological prob-lems from 2.38 to 0.85 points, and pain on genital touching from 1.70 to 0.60 points. Application, tolerability, and medical safety of the formula were good. The phytotherapeutic compounded preparation Di-oscorea comp. ovule (Dioscorea villosa, Glycine max, Salvia officinalis) is suitable for the treatment of urogenital atrophy and its sequelae. A preprint version of the study has been available since July 16, 2020 on www.authorea.com [DOI: 10.22541/au.159493095.52457248].

Sections du résumé

BACKGROUND BACKGROUND

Urogenital atrophy and its sequelae, particularly genital dry-ness, urological problems, and pain on genital touching, are common medi-cal problems for menopausal women and women undergoing antihormonal cancer treatment. To meet the requirements for a nonhormonal local treatment, a compounded herbal preparation was developed as a vaginal ovule (Dioscorea comp. ovulum), and the efficacy and applicability of this herbal treatment were investigated.

PATIENTS AND METHODS METHODS

This was a retrospective chart review of patients' records. The study was approved by the Ethics Committee of the Canton of Zurich (project number BASEC 2016-01982). Between 2007 and 2011, patients with urogenital atrophy and related symptoms, who wanted to initiate herbal treatment, were asked for consent to be interviewed (4-point rating scale) and examined gynecologi-cally with photo documentation of their vaginal discharge. A total of 26 pa-tients met the enrollment criteria and consented to the procedure. Treat-ment: The first 8 weeks consisted of a daily application of low-dose Di-oscorea comp. ovulum followed by high-dose Dioscorea comp. ovule twice weekly for at least 3 months.

RESULT RESULTS

A total of 23 patients completed the trial. Of the 19 patients in the subgroup with an atrophic vaginal maturation index (VMI), 16 achieved a eutrophic VMI. Four patients began therapy with hypotrophy. There was a 96% decrease in complaints (22/23). The genital dryness score decreased from 1.80 to 0.25 points, urological prob-lems from 2.38 to 0.85 points, and pain on genital touching from 1.70 to 0.60 points. Application, tolerability, and medical safety of the formula were good.

CONCLUSION CONCLUSIONS

The phytotherapeutic compounded preparation Di-oscorea comp. ovule (Dioscorea villosa, Glycine max, Salvia officinalis) is suitable for the treatment of urogenital atrophy and its sequelae. A preprint version of the study has been available since July 16, 2020 on www.authorea.com [DOI: 10.22541/au.159493095.52457248].

Identifiants

DOI: 10.1159/000536193 PMID: 38211573

pubmed: 38211573

pii: 000536193

doi: 10.1159/000536193

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

The Author(s). Published by S. Karger AG, Basel.

Herbal treatment of female urogenital atrophy: A retrospective cohort analysis.

Journal

Informations de publication