Eremane, viscidane and isozizaene diterpenoids from the leaves of Eremophila rigida and their absolute configurations.
Eremane diterpenoid
Eremophila rigida Chinnock
High-resolution inhibition profiling
Isozizaene diterpenoid
Protein tyrosine phosphatase 1B inhibitors
Scrophulariaceae
Viscidane diterpenoid
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
09 Jan 2024
09 Jan 2024
Historique:
received:
01
08
2023
revised:
02
01
2024
accepted:
06
01
2024
medline:
12
1
2024
pubmed:
12
1
2024
entrez:
11
1
2024
Statut:
aheadofprint
Résumé
Previously undescribed eremane, viscidane, and isozizaene diterpenoids, eremorigidanes A-F, along with six known O-methylated flavonoids and three known triterpenoids were isolated and identified from the leaves of Eremophila rigida Chinnock by combined use of high-resolution PTP1B inhibition profiling, semipreparative- and analytical-scale HPLC separations, HPLC-PDA-HRMS analysis, and NMR spectroscopy. The absolute configuration of the unreported diterpenoids were determined by comparison of their experimental and calculated ECD spectra as well as by biosynthetic arguments. All isolates were evaluated for their PTP1B inhibitory activities, which revealed the flavonoid penduletin (3) to show inhibition with an IC
Identifiants
pubmed: 38211848
pii: S0031-9422(24)00009-8
doi: 10.1016/j.phytochem.2024.113972
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113972Informations de copyright
Copyright © 2024. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.