Amplitude-determined seizure-threshold, electric field modeling, and electroconvulsive therapy antidepressant and cognitive outcomes.


Journal

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907

Informations de publication

Date de publication:
11 Jan 2024
Historique:
received: 03 08 2023
accepted: 26 11 2023
revised: 06 11 2023
medline: 12 1 2024
pubmed: 12 1 2024
entrez: 11 1 2024
Statut: aheadofprint

Résumé

Electroconvulsive therapy (ECT) pulse amplitude, which dictates the induced electric field (E-field) magnitude in the brain, is presently fixed at 800 or 900 milliamperes (mA) without clinical or scientific rationale. We have previously demonstrated that increased E-field strength improves ECT's antidepressant effect but worsens cognitive outcomes. Amplitude-determined seizure titration may reduce the E-field variability relative to fixed amplitude ECT. In this investigation, we assessed the relationships among amplitude-determined seizure-threshold (ST

Identifiants

pubmed: 38212442
doi: 10.1038/s41386-023-01780-4
pii: 10.1038/s41386-023-01780-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH125126
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH128692
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH128692
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : MH119285
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : ZIAMH002955

Informations de copyright

© 2024. The Author(s).

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Auteurs

Christopher C Abbott (CC)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA. cabbott@salud.unm.edu.

Jeremy Miller (J)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Danielle Farrar (D)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Miklos Argyelan (M)

Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY, USA.
Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY, USA.

Megan Lloyd (M)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Taylor Squillaci (T)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Brian Kimbrell (B)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Sephira Ryman (S)

Mind Research Network, Albuquerque, NM, USA.
Department of Neurology, Albuquerque, NM, USA.

Thomas R Jones (TR)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Joel Upston (J)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Davin K Quinn (DK)

Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA.

Angel V Peterchev (AV)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA.
Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA.

Erik Erhardt (E)

Department of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, USA.

Abhishek Datta (A)

Soterix Medical, New York, NY, USA.

Shawn M McClintock (SM)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Division of Psychology, Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.

Zhi-De Deng (ZD)

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.
Noninvasive Neuromodulation Unit, Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Classifications MeSH