Cytotoxicity of Prymnesium parvum extracts and prymnesin analogs on epithelial fish gill cells RTgill-W1 and the human colon cell line HCEC-1CT.
Fluorescence microscopy
Ichthyotoxin
Ionoregulation
MS
Microalgae
UHPLC
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
11 Jan 2024
11 Jan 2024
Historique:
received:
27
10
2023
accepted:
07
12
2023
medline:
12
1
2024
pubmed:
12
1
2024
entrez:
11
1
2024
Statut:
aheadofprint
Résumé
Harmful algal blooms kill fish populations worldwide, as exemplified by the haptophyte microalga Prymnesium parvum. The suspected causative agents are prymnesins, categorized as A-, B-, and C-types based on backbone carbon atoms. Impacts of P. parvum extracts and purified prymnesins were tested on the epithelial rainbow trout fish gill cell line RTgill-W1 and on the human colon epithelial cells HCEC-1CT. Cytotoxic potencies ranked A > C > B-type with concentrations spanning from low (A- and C-type) to middle (B-type) nM ranges. Although RTgill-W1 cells were about twofold more sensitive than HCEC-1CT, the cytotoxicity of prymnesins is not limited to fish gills. Both cell lines responded rapidly to prymnesins; with EC
Identifiants
pubmed: 38212450
doi: 10.1007/s00204-023-03663-5
pii: 10.1007/s00204-023-03663-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Austrian Science Fund
ID : J3895-N28
Organisme : Austrian Science Fund
ID : I-5707
Organisme : Innovationsfonden
ID : 4097-00007B
Organisme : Innovationsfonden
ID : 0603-00449B
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 766327
Informations de copyright
© 2024. The Author(s).
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