Multisystem inflammatory syndrome in children (MIS-C): A nationwide collaborative study in the Greek population.

COVID-19 MIS-C Multisystem inflammatory syndrome in children PIM-TS Paediatric inflammatory multisystem syndrome SARS-CoV-2

Journal

European journal of pediatrics

ISSN: 1432-1076

Titre abrégé: Eur J Pediatr

Pays: Germany

ID NLM: 7603873

Informations de publication

Date de publication:
12 Jan 2024

Historique:

received: 10 08 2023

accepted: 10 12 2023

revised: 05 12 2023

medline: 12 1 2024

pubmed: 12 1 2024

entrez: 12 1 2024

Statut: aheadofprint

Résumé

Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe hyperinflammatory condition that may occur following SARS-CoV-2 infection. This retrospective, descriptive study of children hospitalized with multisystem inflammatory syndrome in children (MIS-C) in 12 tertiary care centers from 3/11/2020 to 12/31/2021. Demographics, clinical and laboratory characteristics, treatment and outcomes are described. Among 145 patients (95 males, median age 8.2 years) included, 123 met the WHO criteria for MIS-C, while 112 (77%) had serological evidence of SARS-CoV-2 infection. Fever was present in 99%, gastrointestinal symptoms in 77%, mucocutaneous involvement in 68% and respiratory symptoms in 28%. Fifty-five patients (38%) developed myocarditis, 29 (20%) pericarditis and 19 (13%) coronary aneurysms. Among the above cases 11/55 (20%), 1/29 (3.4%) and 5/19 (26.3%), respectively, cardiac complications had not fully resolved at discharge. Underlying comorbidities were reported in 18%. Median CRP value was 155 mg/l, ferritin 535 ng/ml, PCT 1.6 ng/ml and WBC 14.2 × 10 MIS-C is a novel, infrequent but serious disease entity. Cardiac manifestations included myocarditis and pericarditis, which resolved in most patients before discharge. Timely initiation of immunomodulatory therapy was shown to be effective. NT-pro-BNP levels may provide a better prediction and monitoring of the disease course. Further research is required to elucidate the pathogenesis, risk factors and optimal management, and long-term outcomes of this clinical entity. • MIS-C is an infrequent but serious disease entity. • Patients with MIS-C present with multi-organ dysfunction, primarily involving the gastrointestinal and cardiovascular systems. • NT-pro-BNP levels may provide a better prediction and monitoring of the disease course. • Acute kidney injury and/or myocarditis were associated with higher risk of developing shock.

Identifiants

DOI: 10.1007/s00431-023-05383-5 PMID: 38214810

pubmed: 38214810

doi: 10.1007/s00431-023-05383-5

pii: 10.1007/s00431-023-05383-5

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

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