The immunoglobulin J chain is an evolutionarily co-opted chemokine.
evolution
gene family
immunoglobulin
synteny
vertebrate
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
16 Jan 2024
16 Jan 2024
Historique:
medline:
12
1
2024
pubmed:
12
1
2024
entrez:
12
1
2024
Statut:
ppublish
Résumé
The joining (J) chain regulates polymerization of multimeric Immunoglobulin(Ig)M and IgA, forming a disulfide bond to the C termini of their Ig heavy chains, and it controls IgM/IgA transport across mucosal epithelia. Like Ig itself and human-like adaptive immunity, J chain emerged in jawed vertebrates (gnathostomes), but its origin has remained mysterious since its discovery over 50 y ago. Here, we show unexpectedly that J chain is a member of the CXCL chemokine family. The J chain gene (
Identifiants
pubmed: 38215184
doi: 10.1073/pnas.2318995121
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2318995121Subventions
Organisme : HHS | NIH | NIAID | Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)
ID : R01AI140326
Organisme : HHS | NIH | NIAID | Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID)
ID : R01AI170847
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.