Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells.

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
12 Jan 2024
Historique:
medline: 12 1 2024
pubmed: 12 1 2024
entrez: 12 1 2024
Statut: ppublish

Résumé

Defective FAS (CD95/Apo-1/TNFRSF6) signaling causes autoimmune lymphoproliferative syndrome (ALPS). Hypergammaglobulinemia is a common feature in ALPS with

Identifiants

DOI: 10.1126/sciimmunol.adj5948 PMID: 38215192
pubmed: 38215192
doi: 10.1126/sciimmunol.adj5948
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj5948

Auteurs

Julian Staniek (J)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Faculty of Biology, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-4050-2772

Tomas Kalina (T)

Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
ORCID: 0009-0008-5335-9515

Geoffroy Andrieux (G)

Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK), partner site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-5389-9481

Melanie Boerries (M)

Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK), partner site Freiburg, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-3670-0602

Iga Janowska (I)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0009-0004-7526-2803

Manuel Fuentes (M)

Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain.
ORCID: 0000-0002-7305-3766

Paula Díez (P)

Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain.
Department of Immunology, Leiden University Medical Center, Leiden, Netherlands.
ORCID: 0000-0003-2150-6898

Marina Bakardjieva (M)

Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
ORCID: 0000-0002-5919-6306

Jitka Stancikova (J)

Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
ORCID: 0000-0003-1059-3404

Jan Raabe (J)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-6894-1451

Julika Neumann (J)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-0518-2512

Sabine Schwenk (S)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0009-0002-5896-6716

Leonardo Arpesella (L)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0009-0006-5779-0981

Jan Stuchly (J)

Department of Paediatric Haematology and Oncology, Second Faculty of Medicine, Charles University, Prague, Czech Republic.

Vladimir Benes (V)

Genomics Core Facility, European Molecular Biology Laboratory, Heidelberg, Germany.
ORCID: 0000-0002-0352-2547

Rodrigo García Valiente (R)

Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain.
ORCID: 0000-0003-0444-5587

Jonatan Fernández García (J)

Department of Medicine and General Cytometry Service-Nucleus, Proteomics Unit, CIBERONC CB16/12/00400, Cancer Research Center (IBMCC/CSIC/USAL/IBSAL), Universidad de Salamanca, Salamanca, Spain.
ORCID: 0000-0003-3676-7855

Rita Carsetti (R)

B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
ORCID: 0000-0002-2632-1078

Eva Piano Mortari (E)

B Cell Unit, Immunology Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
ORCID: 0000-0002-0054-4732

Albert Catala (A)

Department of Hematology, Institut de Recerca Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.
ORCID: 0000-0003-0133-1752

Oscar de la Calle (O)

Immunology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
ORCID: 0000-0001-9717-053X

Georgios Sogkas (G)

Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.
ORCID: 0000-0003-0855-2945

Bénédicte Neven (B)

Pediatric Hematology-Immunology and Rheumatology Department, University Hospital Necker-Enfants Malades, Paris, France.

Frédéric Rieux-Laucat (F)

Université de Paris, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, INSERM UMR 1163, Paris, France.
ORCID: 0000-0001-7858-7866

Aude Magerus (A)

Université de Paris, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, Imagine Institute, INSERM UMR 1163, Paris, France.
ORCID: 0000-0001-7365-699X

Olaf Neth (O)

Department of Paediatric Infectious Diseases, Rheumatology and Immunology, Hospital Universitario Virgen del Rocio (HUVR), Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla/CSIC, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Sevilla, Spain.
ORCID: 0000-0001-5018-0466

Peter Olbrich (P)

Department of Paediatric Infectious Diseases, Rheumatology and Immunology, Hospital Universitario Virgen del Rocio (HUVR), Instituto de Biomedicina de Sevilla (IBIS), Universidad de Sevilla/CSIC, Red de Investigación Traslacional en Infectología Pediátrica RITIP, Sevilla, Spain.
ORCID: 0000-0001-9853-7903

Reinhard E Voll (RE)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-5542-9133

Laia Alsina (L)

Department of Hematology, Institut de Recerca Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.
Clinical Immunology and Primary Immunodeficiencies Unit, Department of Pediatric Allergy and Clinical Immunology, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain.
ORCID: 0000-0002-3559-0018

Luis M Allende (LM)

Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.
ORCID: 0000-0001-9586-8539

Luis I Gonzalez-Granado (LI)

Primary Immunodeficiencies Unit, Department of Pediatrics, Research Institute Hospital 12 Octubre (i+12), Madrid, Spain.
School of Medicine, Complutense University, Madrid, Spain.
ORCID: 0000-0001-6917-8980

Chiara Böhler (C)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Jens Thiel (J)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Division of Rheumatology and Clinical Immunology, Medical University Graz, Graz, Austria.

Nils Venhoff (N)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0001-7729-2759

Raquel Lorenzetti (R)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Division of Rheumatology and Clinical Immunology, Medical University Graz, Graz, Austria.
ORCID: 0009-0008-0184-1609

Klaus Warnatz (K)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Immunology, University Hospital Zurich, Zurich, Switzerland.
ORCID: 0000-0002-1172-865X

Susanne Unger (S)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0001-6916-7544

Maximilian Seidl (M)

Department of Pathology, University Medical Center Freiburg, Freiburg, Germany.
Institute of Pathology, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany.
ORCID: 0000-0002-5559-4980

Dirk Mielenz (D)

Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus Fiebiger Zentrum, Friedrich Alexander University Erlangen-Nürnberg, Erlangen, Germany.
ORCID: 0000-0002-1135-0642

Pascal Schneider (P)

Department of Immunobiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.

Stephan Ehl (S)

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-9265-2721

Anne Rensing-Ehl (A)

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-7031-0018

Cristian Roberto Smulski (CR)

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Medical Physics Department, Centro Atómico Bariloche, Comisión Nacional de Energía Atómica (CNEA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), San Carlos de Bariloche, Argentina.
ORCID: 0000-0003-4186-8116

Marta Rizzi (M)

Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Center for Chronic Immunodeficiency, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-5153-6089

Classifications MeSH