Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.
Journal
Nature ecology & evolution
ISSN: 2397-334X
Titre abrégé: Nat Ecol Evol
Pays: England
ID NLM: 101698577
Informations de publication
Date de publication:
12 Jan 2024
12 Jan 2024
Historique:
received:
06
04
2023
accepted:
04
12
2023
medline:
13
1
2024
pubmed:
13
1
2024
entrez:
12
1
2024
Statut:
aheadofprint
Résumé
Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hypothesis suggests that two WGD events (1R and 2R) occurred during early vertebrate evolution. However, the timing of the 2R event relative to the divergence of gnathostomes (jawed vertebrates) and cyclostomes (jawless hagfishes and lampreys) is unresolved and whether these WGD events underlie vertebrate phenotypic diversification remains elusive. Here we present the genome of the inshore hagfish, Eptatretus burgeri. Through comparative analysis with lamprey and gnathostome genomes, we reconstruct the early events in cyclostome genome evolution, leveraging insights into the ancestral vertebrate genome. Genome-wide synteny and phylogenetic analyses support a scenario in which 1R occurred in the vertebrate stem-lineage during the early Cambrian, and 2R occurred in the gnathostome stem-lineage, maximally in the late Cambrian-earliest Ordovician, after its divergence from cyclostomes. We find that the genome of stem-cyclostomes experienced an additional independent genome triplication. Functional genomic and morphospace analyses demonstrate that WGD events generally contribute to developmental evolution with similar changes in the regulatory genome of both vertebrate groups. However, appreciable morphological diversification occurred only in the gnathostome but not in the cyclostome lineage, calling into question the general expectation that WGDs lead to leaps of bodyplan complexity.
Identifiants
pubmed: 38216617
doi: 10.1038/s41559-023-02299-z
pii: 10.1038/s41559-023-02299-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 19K06798
Organisme : National Science Foundation (NSF)
ID : 1755418
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01AI072435
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R35GM122591
Organisme : John Templeton Foundation (JTF)
ID : 62220
Organisme : John Templeton Foundation (JTF)
ID : 62220
Organisme : RCUK | Natural Environment Research Council (NERC)
ID : NE/P013678/1
Organisme : RCUK | Natural Environment Research Council (NERC)
ID : NE/P013678/1
Organisme : Wellcome Trust (Wellcome)
ID : 108749/Z/15/Z
Organisme : Leverhulme Trust
ID : RF-2022-167
Organisme : RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/T012773/1
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 31970565
Informations de copyright
© 2024. The Author(s).
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