EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP.

Journal

Rhinology
ISSN: 0300-0729
Titre abrégé: Rhinology
Pays: Netherlands
ID NLM: 0347242

Informations de publication

Date de publication:
13 Jan 2024
Historique:
medline: 13 1 2024
pubmed: 13 1 2024
entrez: 13 1 2024
Statut: aheadofprint

Résumé

Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on novel goals of care in CRSwNP. The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) and EPOS expert members discussed how to measure treatment responses and set new treatment goals for CRSwNP. In this paper a consensus on a list of definitions related to CRSwNP is provided: control, remission, cure, recurrence/exacerbation, treatable traits, remodeling, progression, and disease modification. By providing these definitions, the involved experts hope to improve communication between all stakeholders involved in CRSwNP treatment for use in routine care, basic and clinical research and international guidelines aimed to harmonize and optimize standard of care of patients with CRSwNP in the future.

Identifiants

DOI: 10.4193/Rhin23.415 PMID: 38217529
pubmed: 38217529
pii: 3150
doi: 10.4193/Rhin23.415
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

W J Fokkens (WJ)

Department of Otorhinolarynogology and head/neck surgery, Amsterdam University Medical Centres, location AMC, University of Amsterdam, Amsterdam, The Netherlands.

E De Corso (E)

Otolaryngology, Head and Neck Surgery, Rhinology, A. Gemelli Universitary Hospital Foundation, IRCSS, Rome, Italy.

V Backer (V)

Department of Otorhinolaryngology, Head and Neck surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.

M Bernal-Sprekelsen (M)

Department of Otorhinolaryngology, University of Barcelona, Department of Otorhinolaryngology, Clinic Barcelona, Spain.

L Bjermer (L)

Department of Respiratory Medicine and Allergology, Lund University, Skåne University Hospital, Lund, Sweden.

C von Buchwald (C)

Department of Otorhinolaryngology, Head and Neck surgery and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.

A Chaker (A)

Department of Otorhinolaryngology and Center for Allergy and Environment (ZAUM), TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany.

Z Diamant (Z)

Department of Otorhinolaryngology and Center for Allergy and Environment (ZAUM), TUM School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Germany.
Department of Microbiology Immunology and Transplantation, KU Leuven, Catholic University of Leuven, Leuven, Belgium.
Department of Clinical Pharmacy and Pharmacology, UMCG, Groningen, The Netherlands.
Department of Respiratory Medicine and Allergology, Institute for Clinical Science, Skåne University Hospital Lund, Sweden.
D.

P Gevaert (P)

Laboratory of Upper Airways Research, Department of Otorhinolaryngology, University Hospital Ghent, Ghent, Belgium.

J Han (J)

Department of Otolaryngology and Head and Neck Surgery at Eastern Virginia Medical School, Norfolk, VI, USA.

C Hopkins (C)

Ear, Nose and Throat Department, Guys and St. Thomas Hospital, London, United Kingdom.

V Hox (V)

Department of Otorhinolaryngology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

L Klimek (L)

Center for Rhinology and Allergology, Wiesbaden, Germany.

V J Lund (VJ)

Professorial Unit, Ear Institute, University College London, United Kingdom.

S Lee (S)

Division of Rhinology and Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

A Luong (A)

Department of Otorhinolaryngology, Head and Neck Surgery, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA.

J Mullol (J)

Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic, FRCB-IDIBAPS, Universitat de Barcelona, CIBERES. Barcelona, Catalonia, Spain.

A Peters (A)

Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

O Pfaar (O)

Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.

S Reitsma (S)

Department of Otorhinolarynogology and head/neck surgery, Amsterdam University Medical Centres, location AMC, University of Amsterdam, Amsterdam, The Netherlands.

S Toppila-Salmi (S)

Department of Otorhinolaryngology - Head and Neck Surgery, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.
Department of Allergy, Inflammation Center, Helsinki University Hospital and University of Helsinki , Finland.

G K Scadding (GK)

Division of infection and Immunity, University College London, United Kingdom.

A R Sedaghat (AR)

Department of Otolaryngology - Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

A-S Viskens (AS)

Laboratory of Allergy and Clinical Immunology Research Unit, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.

M Wagenmann (M)

Department of Otorhinolaryngology, Universitätsklinikum Düsseldorf, Dusseldorf, Germany.

P W Hellings (PW)

Department of Otorhinolaryngology, Head and Neck Surgery, UZ Leuven, Leuven, Belgium.

Classifications MeSH