Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population.

Depressive symptoms HbA1c Metabolic syndrome Severity Type 2 diabetes

Journal

Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594

Informations de publication

Date de publication:
13 Jan 2024
Historique:
received: 28 09 2023
accepted: 07 12 2023
medline: 14 1 2024
pubmed: 14 1 2024
entrez: 13 1 2024
Statut: aheadofprint

Résumé

To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up. n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 ± 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control. The presence of T2D increased the likelihood of higher levels of depressive symptoms (χ This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.

Identifiants

pubmed: 38218741
doi: 10.1007/s40618-023-02278-y
pii: 10.1007/s40618-023-02278-y
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Instituto de Salud Carlos III
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ID : PROMETEO/21/2021
Organisme : Generalitat de Catalunya- AGAUR
ID : 2021-SGR-00824
Organisme : Horizon 2020 Framework Programme
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Organisme : Spanish Ministry of Economy, Industry and Competitiveness
ID : IJC2019-042420-I
Organisme : Universitat Rovira i Virgili
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Organisme : Consejería de Salud de la Junta de Andalucía
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Informations de copyright

© 2024. The Author(s).

Références

World Health Organization (2023) Diabetes—Fact Sheet. In: diabetes. https://www.who.int/news-room/fact-sheets/detail/diabetes . Accessed 29 Jun 2023
Soligo M, Morlacco A, Zattoni F et al (2022) Metabolic syndrome and stone disease. Panminerva Med 64:344–358. https://doi.org/10.23736/S0031-0808.21.04517-1
doi: 10.23736/S0031-0808.21.04517-1 pubmed: 34609121
Owens-Gary MD, Zhang X, Jawanda S et al (2019) The importance of addressing depression and diabetes distress in adults with type 2 diabetes. J Gen Intern Med 34:320–324. https://doi.org/10.1007/s11606-018-4705-2
doi: 10.1007/s11606-018-4705-2 pubmed: 30350030
Gois C, Akiskal H, Akiskal K, Luisa Figueira M (2012) Depressive temperament, distress, psychological adjustment and depressive symptoms in type 2 diabetes. J Affect Disord 143:1–4. https://doi.org/10.1016/j.jad.2012.05.028
doi: 10.1016/j.jad.2012.05.028 pubmed: 22901331
Dennick K, Sturt J, Speight J (2017) What is diabetes distress and how can we measure it? A narrative review and conceptual model. J Diabetes Complications 31:898–911
doi: 10.1016/j.jdiacomp.2016.12.018 pubmed: 28274681
Kim JR, Kim HN, Song SW (2018) Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome. Diabetol Metab Syndr. https://doi.org/10.1186/s13098-018-0367-9
doi: 10.1186/s13098-018-0367-9 pubmed: 30186371 pmcid: 6119265
Limon VM, Lee M, Gonzalez B et al (2020) The impact of metabolic syndrome on mental health-related quality of life and depressive symptoms. Qual Life Res 29:2063–2072. https://doi.org/10.1007/s11136-020-02479-5
doi: 10.1007/s11136-020-02479-5 pubmed: 32215841 pmcid: 7513573
Harding KA, Pushpanathan ME, Whitworth SR et al (2019) Depression prevalence in type 2 diabetes is not related to diabetes–depression symptom overlap but is related to symptom dimensions within patient self-report measures: a meta-analysis. Diabet Med 36:1600–1611. https://doi.org/10.1111/dme.14139
doi: 10.1111/dme.14139 pubmed: 31532013
Wang F, Wang S, Zong QQ et al (2019) Prevalence of comorbid major depressive disorder in type 2 diabetes: a meta-analysis of comparative and epidemiological studies. Diabet Med 36:961–969. https://doi.org/10.1111/dme.14042
doi: 10.1111/dme.14042 pubmed: 31127631
Fugger G, Dold M, Bartova L et al (2019) Major depression and comorbid diabetes—findings from the European group for the study of resistant depression. Prog Neuro-Psychopharmacology Biol Psychiatry. https://doi.org/10.1016/j.pnpbp.2019.109638
doi: 10.1016/j.pnpbp.2019.109638
Mansur RB, Brietzke E, McIntyre RS (2015) Is there a “metabolic-mood syndrome”? A review of the relationship between obesity and mood disorders. Neurosci Biobehav Rev 52:89–104. https://doi.org/10.1016/j.neubiorev.2014.12.017
doi: 10.1016/j.neubiorev.2014.12.017 pubmed: 25579847
Postolache TT, del Bosque-Plata L, Jabbour S et al (2019) Co-shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic syndrome. Am J Med Genet Part B Neuropsychiatr Genet 180:186–203. https://doi.org/10.1002/ajmg.b.32712
doi: 10.1002/ajmg.b.32712
Pan A, Keum N, Okereke OI et al (2012) Bidirectional association between depression and metabolic syndrome: a systematic review and meta-analysis of epidemiological studies. Diabetes Care 35:1171–1180. https://doi.org/10.2337/dc11-2055
doi: 10.2337/dc11-2055 pubmed: 22517938 pmcid: 3329841
Martín-Peláez S, Serra-Majem L, Cano-Ibáñez N et al (2022) Contribution of cardio-vascular risk factors to depressive status in the predimed-plus trial. A cross-sectional and a 2-year longitudinal study. PLoS ONE 17:e0265079. https://doi.org/10.1371/journal.pone.0265079
doi: 10.1371/journal.pone.0265079 pubmed: 35417452 pmcid: 9007355
Pano O, Martínez-Lapiscina EH, Sayón-Orea C et al (2021) Healthy diet, depression and quality of life: a narrative review of biological mechanisms and primary prevention opportunities. World J Psychiatry 11:997–1016. https://doi.org/10.5498/wjp.v11.i11.997
doi: 10.5498/wjp.v11.i11.997 pubmed: 34888169 pmcid: 8613751
Mutz J, Lewis CM (2021) Lifetime depression and age-related changes in body composition, cardiovascular function, grip strength and lung function: sex-specific analyses in the UK Biobank. Aging (Albany NY) 13:17038–17079. https://doi.org/10.18632/aging.203275
doi: 10.18632/aging.203275 pubmed: 34233295
Mallorquí-Bagué N, Lozano-Madrid M, Toledo E et al (2018) Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study. Sci Rep. https://doi.org/10.1038/s41598-018-33843-8
doi: 10.1038/s41598-018-33843-8 pubmed: 30382190 pmcid: 6208341
Martínez-González MA, Sánchez-Villegas A (2016) Food patterns and the prevention of depression. Proc Nutr Soc 75:139–146. https://doi.org/10.1017/S0029665116000045
doi: 10.1017/S0029665116000045 pubmed: 26898781
Sánchez-Villegas A, Martínez-González MA, Estruch R et al (2013) Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC Med 11:208. https://doi.org/10.1186/1741-7015-11-208
doi: 10.1186/1741-7015-11-208 pubmed: 24229349 pmcid: 3848350
Sánchez-Villegas A, Álvarez-Pérez J, Toledo E et al (2018) Seafood consumption, omega-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-plus trial. Nutrients. https://doi.org/10.3390/nu10122000
doi: 10.3390/nu10122000 pubmed: 30567286 pmcid: 6315981
Cano-Ibáñez N, Serra-Majem L, Martín-Peláez S et al (2022) Association between the prime diet quality score and depressive symptoms in a mediterranean population with metabolic syndrome. cross-sectional and 2-year follow-up assessment from predimed-plus study. Br J Nutr 128:1170–1179. https://doi.org/10.1017/S0007114521004323
doi: 10.1017/S0007114521004323 pubmed: 34713791
Alberti KGMM, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; Natioaanal heart, lung, and blood institute; American heart association; Woaarld heart federation; Internaaational. Circulation 120:1640–1645. https://doi.org/10.1161/CIRCULATIONAHA.109.192644
doi: 10.1161/CIRCULATIONAHA.109.192644 pubmed: 19805654
Martínez-González MA, Buil-Cosiales P, Corella D et al (2019) Cohort profile: design and methods of the predimed-plus randomized trial. Int J Epidemiol 48:387–388o. https://doi.org/10.1093/IJE/DYY225
doi: 10.1093/IJE/DYY225 pubmed: 30476123
Beck AT, Steer RA, Brown GK (1996) Manual for the beck depression inventory-II. San Antonio, TX Psychol Corp 1:82
Sanz J, Perdigón AL, Vázquez C (2003) Adaptación española del Inventario para la Depresión de Beck-II (BDI-II): 2. Propiedades psicométricas en población general | Revista de psicología. Clínica y Salud 14:249–280
Feldman H, ElSayed NA, McCoy RG et al (2023) Standards of care in diabetes—2023 abridged for primary care providers. Clin Diabetes 41:4–31. https://doi.org/10.2337/cd23-as01
doi: 10.2337/cd23-as01
Schröder H, Zomeño MD, Martínez-González MA et al (2021) Validity of the energy-restricted mediterranean diet adherence screener. Clin Nutr 40:4971–4979. https://doi.org/10.1016/j.clnu.2021.06.030
doi: 10.1016/j.clnu.2021.06.030 pubmed: 34364236
Molina L, Sarmiento M, Peñafiel J et al (2017) Validation of the regicor short physical activity questionnaire for the adult population. PLoS ONE 12:e0168148. https://doi.org/10.1371/JOURNAL.PONE.0168148
doi: 10.1371/JOURNAL.PONE.0168148 pubmed: 28085886 pmcid: 5234797
StataCorp LLC (2021) Stata statistical software: Release 17. College Station, TX
Finner H, Roters M (2001) On the false discovery rate and expected type I errors. Biometrical J 43:985–1005. https://doi.org/10.1002/1521-4036(200112)43:8%3c985::AID-BIMJ985%3e3.0.CO;2-4
doi: 10.1002/1521-4036(200112)43:8<985::AID-BIMJ985>3.0.CO;2-4
Gonzalez JS, Hood KK, Esbitt SA, et al (2018) Psychiatric and psychosocial issues among individuals living with diabetes. In: Cowie CC et al (eds) Diabetes in America. 3rd edn, Chapter 33. National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, pp 1–34
Cantero I, Abete I, Babio N et al (2018) Dietary inflammatory index and liver status in subjects with different adiposity levels within the predimed trial. Clin Nutr 37:1736–1743. https://doi.org/10.1016/j.clnu.2017.06.027
doi: 10.1016/j.clnu.2017.06.027 pubmed: 28734553
Moulton CD, Pickup JC, Ismail K (2015) The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol 3:461–471. https://doi.org/10.1016/S2213-8587(15)00134-5
doi: 10.1016/S2213-8587(15)00134-5 pubmed: 25995124
Martins LB, Braga Tibães JR, Berk M, Teixeira AL (2022) Diabetes and mood disorders: shared mechanisms and therapeutic opportunities. Int J Psychiatry Clin Pract 26:183–195. https://doi.org/10.1080/13651501.2021.1957117
doi: 10.1080/13651501.2021.1957117 pubmed: 34348557
Holt RIG, De Groot M, Golden SH (2014) Diabetes and depression. Curr Diab Rep. https://doi.org/10.1007/s11892-014-0491-3
doi: 10.1007/s11892-014-0491-3 pubmed: 24743941 pmcid: 4476048
Lyra e Silva N de M, Lam MP, Soares CN, et al (2019) Insulin resistance as a shared pathogenic mechanism between depression and type 2 diabetes. Front Psychiatry 10:57
doi: 10.3389/fpsyt.2019.00057 pubmed: 30837902
Doyle T, Halaris A, Rao M (2014) Shared neurobiological pathways between type 2 diabetes and depressive symptoms: a review of morphological and neurocognitive findings. Curr Diab Rep 14:1–12. https://doi.org/10.1007/s11892-014-0560-7
doi: 10.1007/s11892-014-0560-7
Dantzer R, O’Connor JC, Freund GG et al (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56
doi: 10.1038/nrn2297 pubmed: 18073775 pmcid: 2919277
Amare AT, Schubert KO, Klingler-Hoffmann M et al (2017) The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies. Transl Psychiatry. https://doi.org/10.1038/tp.2016.261
doi: 10.1038/tp.2016.261 pubmed: 28117839 pmcid: 5545727
Reynolds KA, Helgeson VS (2011) Children with diabetes compared to peers: depressed? Distressed? A meta-analytic review. Ann Behav Med 42:29–41. https://doi.org/10.1007/s12160-011-9262-4
doi: 10.1007/s12160-011-9262-4 pubmed: 21445720
Fisher L, Glasgow RE, Strycker LA (2010) The relationship between diabetes distress and clinical depression with glycemic control among patients with type 2 diabetes. Diabetes Care 33:1034–1036. https://doi.org/10.2337/dc09-2175
doi: 10.2337/dc09-2175 pubmed: 20150291 pmcid: 2858170
Gonzalez JS, Safren SA, Cagliero E et al (2007) Depression, self-care, and medication adherence in type 2 diabetes: relationships across the full range of symptom severity. Diabetes Care 30:2222–2227. https://doi.org/10.2337/dc07-0158
doi: 10.2337/dc07-0158 pubmed: 17536067
Paans NPG, Bot M, Brouwer IA et al (2018) The association between depression and eating styles in four European countries: the MooDFOOD prevention study. J Psychosom Res 108:85–92. https://doi.org/10.1016/j.jpsychores.2018.03.003
doi: 10.1016/j.jpsychores.2018.03.003 pubmed: 29602330
Mills JG, Thomas SJ, Larkin TA, Deng C (2020) Overeating and food addiction in major depressive disorder: links to peripheral dopamine. Appetite. https://doi.org/10.1016/j.appet.2020.104586
doi: 10.1016/j.appet.2020.104586 pubmed: 32768601
Wermeling M, Thiele-Manjali U, Koschack J et al (2014) Type 2 diabetes patients’ perspectives on lifestyle counselling and weight management in general practice: a qualitative study. BMC Fam Pract. https://doi.org/10.1186/1471-2296-15-97
doi: 10.1186/1471-2296-15-97 pubmed: 24885605 pmcid: 4027991
Kane NS, Hoogendoorn CJ, Tanenbaum ML, Gonzalez JS (2018) Physical symptom complaints, cognitive emotion regulation strategies, self-compassion and diabetes distress among adults with type 2 diabetes. Diabet Med 35:1671–1677. https://doi.org/10.1111/dme.13830
doi: 10.1111/dme.13830 pubmed: 30264898 pmcid: 7313242
Rubin RR, Peyrot M (2001) Psychological issues and treatments for people with diabetes. J Clin Psychol 57:457–478. https://doi.org/10.1002/jclp.1041
doi: 10.1002/jclp.1041 pubmed: 11255202
Olesen K, Folmann Hempler N, Drejer S et al (2020) Impact of patient-centred diabetes self-management education targeting people with type 2 diabetes: an integrative review. Diabet Med 37:909–923. https://doi.org/10.1111/dme.14284
doi: 10.1111/dme.14284 pubmed: 32124483
Cheng L, Sit JWH, Choi K, chow, et al (2018) Effectiveness of a patient-centred, empowerment-based intervention programme among patients with poorly controlled type 2 diabetes: a randomised controlled trial. Int J Nurs Stud 79:43–51. https://doi.org/10.1016/j.ijnurstu.2017.10.021
doi: 10.1016/j.ijnurstu.2017.10.021 pubmed: 29149618
White RL, Babic MJ, Parker PD et al (2017) Domain-specific physical activity and mental health: a meta-analysis. Am J Prev Med 52:653–666. https://doi.org/10.1016/j.amepre.2016.12.008
doi: 10.1016/j.amepre.2016.12.008 pubmed: 28153647
Carter J, Swardfager W (2016) Mood and metabolism: anhedonia as a clinical target in type 2 diabetes. Psychoneuroendocrinology 69:123–132. https://doi.org/10.1016/j.psyneuen.2016.04.002
doi: 10.1016/j.psyneuen.2016.04.002 pubmed: 27088371
Hoffmann MS, Brunoni AR, Stringaris A et al (2021) Common and specific aspects of anxiety and depression and the metabolic syndrome. J Psychiatr Res 137:117–125. https://doi.org/10.1016/j.jpsychires.2021.02.052
doi: 10.1016/j.jpsychires.2021.02.052 pubmed: 33677215
Vancampfort D, Firth J, Schuch FB et al (2017) Sedentary behavior and physical activity levels in people with schizophrenia, bipolar disorder and major depressive disorder: a global systematic review and meta-analysis. World Psychiatry 16:308–315. https://doi.org/10.1002/wps.20458
doi: 10.1002/wps.20458 pubmed: 28941119 pmcid: 5608847
Mikkelsen K, Stojanovska L, Polenakovic M et al (2017) Exercise and mental health. Maturitas 106:48–56. https://doi.org/10.1016/j.maturitas.2017.09.003
doi: 10.1016/j.maturitas.2017.09.003 pubmed: 29150166
Schmidt CB, van Loon BJP, Vergouwen ACM et al (2018) Systematic review and meta-analysis of psychological interventions in people with diabetes and elevated diabetes-distress. Diabet Med 35:1157–1172. https://doi.org/10.1111/dme.13709
doi: 10.1111/dme.13709
American Diabetes Association (ADA) (2023) Mental health toolkit | American diabetes association. In: diabetes. https://professional.diabetes.org/meetings/mental-health-toolkit . Accessed 29 Jun 2023
Jacka FN, O’Neil A, Opie R et al (2017) A randomised controlled trial of dietary improvement for adults with major depression (the “SMILES” trial). BMC Med. https://doi.org/10.1186/s12916-017-0791-y
doi: 10.1186/s12916-017-0791-y pubmed: 28137247 pmcid: 5282719

Auteurs

I Baenas (I)

Eating Disorders Unit, Clinical Psychology Department, University Hospital of Bellvitge, Feixa Llarga s/n, Hospitalet de Llobregat, 08907, Barcelona, Spain.
Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute-IDIBELL, 08908, Barcelona, Spain.
Doctoral Program in Medicine and Translational Research, University of Barcelona, 08007, Barcelona, Spain.

L Camacho-Barcia (L)

Eating Disorders Unit, Clinical Psychology Department, University Hospital of Bellvitge, Feixa Llarga s/n, Hospitalet de Llobregat, 08907, Barcelona, Spain.
Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute-IDIBELL, 08908, Barcelona, Spain.

R Granero (R)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute-IDIBELL, 08908, Barcelona, Spain.
Department de Psicobiologia I Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona, 08193, Barcelona, Spain.

C Razquin (C)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, 31008, Pamplona, Spain.

D Corella (D)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine, University of Valencia, 46010, Valencia, Spain.

C Gómez-Martínez (C)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Human Nutrition Unit ANUT-DSM, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007, Reus, Spain.

O Castañer-Niño (O)

Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d`Investigació Médica (IMIM), 08003, Barcelona, Spain.
CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.

J A Martínez (JA)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain.
Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, CEI UAM + CSIC, 28049, Madrid, Spain.

Á M Alonso-Gómez (ÁM)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Cardiovascular, Respiratory and Metabolic Area, Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, 01009, Vitoria-Gasteiz, Spain.

J Wärnberg (J)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Nursing, University of Málaga, Institute of Biomedical Research in Malaga (IBIMA), 29590, Málaga, Spain.

J Vioque (J)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), 03010, Alicante, Spain.

D Romaguera (D)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, 07120, Palma, Spain.

J López-Miranda (J)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain.

R Estruch (R)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036, Barcelona, Spain.

F J Tinahones (FJ)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria Hospital, University of Málaga, 29590, Málaga, Spain.

J Lapetra (J)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41013, Seville, Spain.

J L Serra-Majem (JL)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35016, Las Palmas de Gran Canaria, Spain.

N Cano-Ibáñez (N)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Granada, 18071, Granada, Spain.
Instituto de Investigación Biosanitaria de Granada (IBS.GRANADA), 18012, Granada, Spain.

J A Tur (JA)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, 07122, Palma, Spain.

V Martín-Sánchez (V)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Institute of Biomedicine (IBIOMED), University of León, 24071, León, Spain.

X Pintó (X)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge-IDIBELL, Universidad de Barcelona, 08908, Barcelona, Spain.

J J Gaforio (JJ)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Departamento de Ciencias de la Salud, Instituto Universitario de Investigación en Olivar y Aceites de Oliva, Universidad de Jaén, 23071, Jaén, Spain.

P Matía-Martín (P)

Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), 28040, Madrid, Spain.

J Vidal (J)

CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain.
Department of Endocrinology, Institut d` Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036, Barcelona, Spain.

C Vázquez (C)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Endocrinology and Nutrition, Hospital Fundación Jimenez Díaz, Instituto de Investigaciones Biomédicas IISFJD. University Autonoma, 28024, Madrid, Spain.

L Daimiel (L)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Departamento de Ciencias Farmacéuticas y de la Salud, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, 28668, Madrid, Spain.

E Ros (E)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Lipid Clinic, Hospital Clínic, 08036, Barcelona, Spain.

S Jiménez-Murcia (S)

Eating Disorders Unit, Clinical Psychology Department, University Hospital of Bellvitge, Feixa Llarga s/n, Hospitalet de Llobregat, 08907, Barcelona, Spain.
Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute-IDIBELL, 08908, Barcelona, Spain.
Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, 08907, Barcelona, Spain.

S Dalsgaard (S)

NCRR-National Centre for Register-Based Research, Aarhus University, 8210, Aarhus, Denmark.
iPSYCH-The Lundbeck Foundation Initiative for Integrative Psychiatric Research, 8210, Aarhus, Denmark.
CIRRAU-Centre for Integrated Register-Based Research, Aarhus University, 8210, Aarhus, Denmark.

A Garcia-Arellano (A)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, 31008, Pamplona, Spain.

N Babio (N)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Human Nutrition Unit ANUT-DSM, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007, Reus, Spain.

J V Sorli (JV)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine, University of Valencia, 46010, Valencia, Spain.

C Lassale (C)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Barcelona Institute for Global Health (ISGlobal), 08036, Barcelona, Spain.

M García-de-la-Hera (M)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), 03010, Alicante, Spain.

E Gómez-García (E)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Nursing, University of Málaga, Institute of Biomedical Research in Malaga (IBIMA), 29590, Málaga, Spain.

M A Zulet (MA)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain.
Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, CEI UAM + CSIC, 28049, Madrid, Spain.

J Konieczna (J)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases, 07120, Palma, Spain.

S Martín-Peláez (S)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Granada, 18071, Granada, Spain.

L Tojal-Sierra (L)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Cardiovascular, Respiratory and Metabolic Area, Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, 01009, Vitoria-Gasteiz, Spain.

F J Basterra-Gortari (FJ)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, 31008, Pamplona, Spain.
Department of Endocrinology and Nutrition, Hospital Universitario de Navarra, IdiSNA, Universidad Pública de Navarra, 31008, Pamplona, Spain.

S de Las Heras-Delgado (S)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Human Nutrition Unit ANUT-DSM, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007, Reus, Spain.

O Portoles (O)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, 31008, Pamplona, Spain.

M Á Muñoz-Pérez (MÁ)

Unitat de Suport a la Recerca en Atenció Primaria de Barcelona. IDIAP Jordi Gol. Primary Care Division, Institut Català de La Salut, 08007, Barcelona, Spain.

A P Arenas-Larriva (AP)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain.

L Compañ-Gabucio (L)

CIBER de Epidemiología y Salud Pública (CIBEResp), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Instituto de Investigación Sanitaria y Biomédica de Alicante, Universidad Miguel Hernández (ISABIAL-UMH), 03010, Alicante, Spain.

S Eguaras (S)

Department of Preventive Medicine and Public Health, University of Navarra, IDISNA, 31008, Pamplona, Spain.

S Shyam (S)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Human Nutrition Unit ANUT-DSM, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201, Reus, Spain.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007, Reus, Spain.

M Fitó (M)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Unit of Cardiovascular Risk and Nutrition, Institut Hospital del Mar de Investigaciones Médicas Municipal d`Investigació Médica (IMIM), 08003, Barcelona, Spain.

R M Baños (RM)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Personality, Evaluation and Psychological Treatment of the University of Valencia, 46010, Valencia, Spain.

J Salas-Salvadó (J)

Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain. jordi.salas@urv.cat.
Human Nutrition Unit ANUT-DSM, Biochemistry and Biotechnology Department, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201, Reus, Spain. jordi.salas@urv.cat.
Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007, Reus, Spain. jordi.salas@urv.cat.

F Fernández-Aranda (F)

Eating Disorders Unit, Clinical Psychology Department, University Hospital of Bellvitge, Feixa Llarga s/n, Hospitalet de Llobregat, 08907, Barcelona, Spain. ffernandez@bellvitgehospital.cat.
Centro de Investigación Biomédica en Red, Fisiopatología de la Obesidad y la Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029, Madrid, Spain. ffernandez@bellvitgehospital.cat.
Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Programme, Bellvitge Biomedical Research Institute-IDIBELL, 08908, Barcelona, Spain. ffernandez@bellvitgehospital.cat.
Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, 08907, Barcelona, Spain. ffernandez@bellvitgehospital.cat.

Classifications MeSH