Ratiometric electrogenerated chemiluminescence sensing microRNA based on electrochemically controlled release of lucigenin from silica/chitosan/lucigenin nanoparticles.

The dye-doped silica nanoparticles-based electrogenerated chemiluminescence (ECL) has been widely explored for analytical purposes due to its high sensitivity, simplicity and wide dynamic concentration range. However, only a few of dye molecules located at the near surface of nanoparticles can participate in the ECL reaction due to the poor conductivity of silica nano-matrix. In addition, the ECL signal is easy to be affected by environmental interference, which results in poor accuracy. Herein, a ratiometric ECL sensing method is established based on the electrochemically controlled release of lucigenin molecules from silica/chitosan/lucigenin composite nanoparticles (Lu/CS NPs) with the aid of sulfide ions. Firstly, H

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.