Secretin: a hormone for HCO

Al-Ghimlas F, Faughnan ME, Tullis E (2012) Metabolic alkalosis in adults with stable cystic fibrosis. Open Respir Med J 6:59–62. https://doi.org/10.2174/1874306401206010059;TORMJ-6-59[pii]

doi: 10.2174/1874306401206010059;TORMJ-6-59[pii] pubmed: 22905070 pmcid: 3415624

Amlal H, Petrovic S, Xu J, Wang Z, Sun X, Barone S, Soleimani M (2010) Deletion of the anion exchanger Slc26a4 (pendrin) decreases apical Cl(-)/HCO3(-) exchanger activity and impairs bicarbonate secretion in kidney collecting duct. Am J Physiol Cell Physiol 299:C33-41. https://doi.org/10.1152/ajpcell.00033.2010

doi: 10.1152/ajpcell.00033.2010 pubmed: 20375274 pmcid: 2904254

Azroyan A, Morla L, Crambert G, Laghmani K, Ramakrishnan S, Edwards A, Doucet A (2012) Regulation of pendrin by cAMP: possible involvement in β-adrenergic-dependent NaCl retention. Am J Physiol Renal Physiol 302:F1180-1187. https://doi.org/10.1152/ajprenal.00403.2011

doi: 10.1152/ajprenal.00403.2011 pubmed: 22262479

Bayliss WM, Starling EH (1902) The mechanism of pancreatic secretion. J Physiol 28:325–353

doi: 10.1113/jphysiol.1902.sp000920 pubmed: 16992627 pmcid: 1540572

Bell D, McDermott BJ (1994) Secretin and vasoactive intestinal peptide are potent stimulants of cellular contraction and accumulation of cyclic AMP in rat ventricular cardiomyocytes. J Cardiovasc Pharmacol 23:959–969

doi: 10.1097/00005344-199406000-00015 pubmed: 7523789

Berg P, Andersen JF, Sørensen MV, Wang T, Malte H, Leipziger J (2022) Alkalosis-induced hypoventilation in cystic fibrosis: The importance of efficient renal adaptation. Proc Natl Acad Sci U S A 119(8):e2116836119. https://doi.org/10.1073/pnas.2116836119

Berg P, Jensen T, Andersen JF, Svendsen SL, Modvig IM, Wang T, Frische S, Chow BKC, Malte H, Holst JJ, Sørensen MV, Leipziger J (2023) Loss of the Secretin receptor impairs renal bicarbonate excretion and aggravates metabolic alkalosis in mice during acute base-loading. J Am Soc Nephrol. https://doi.org/10.1681/asn.0000000000000173

doi: 10.1681/asn.0000000000000173 pubmed: 37344929

Berg P, Jeppesen M, Leipziger J (2021) Cystic fibrosis in the kidney: new lessons from impaired renal HCO3- excretion. Curr Opin Nephrol Hypertens 30:437–443. https://doi.org/10.1097/MNH.0000000000000725

doi: 10.1097/MNH.0000000000000725 pubmed: 34027905

Berg P, Sorensen MV, Rousing AQ, Vebert Olesen H, Jensen-Fangel S, Jeppesen M, Leipziger J (2022) Challenged urine bicarbonate excretion as a measure of cystic fibrosis transmembrane conductance regulator function in cystic fibrosis. Ann Intern Med 175:1543–1551. https://doi.org/10.7326/m22-1741

doi: 10.7326/m22-1741 pubmed: 36315944

Berg P, Svendsen SL, Hoang TTL, Praetorius HA, Sorensen MV, Leipziger J (2020) Impaired renal HCO3 (-) secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading. Acta Physiol (Oxf). 2021 Mar 231(3):e13591. https://doi.org/10.1111/apha.13591

Berg P, Svendsen SL, Sorensen MV, Larsen CK, Andersen JF, Jensen-Fangel S, Jeppesen M, Schreiber R, Cabrita I, Kunzelmann K, Leipziger J (2020) Impaired renal HCO3 (-) excretion in cystic fibrosis. J Am Soc Nephrol 31:1711–1727. https://doi.org/10.1681/ASN.2020010053

doi: 10.1681/ASN.2020010053 pubmed: 32703846 pmcid: 7460909

Berg P, Svendsen SL, Sorensen MV, Schreiber R, Kunzelmann K, Leipziger J (2021) The molecular mechanism of CFTR- and secretin-dependent renal bicarbonate excretion. J Physiol 599:3003–3011. https://doi.org/10.1113/JP281285

doi: 10.1113/JP281285 pubmed: 33963548

Bretscher DSA, Hagmann R, Hadorn B, Howald B, Lüthi C, Oetliker O (1974) Response of renal handling of sodium (Na) and bicarbonate (HCO3) to secretin in normals and patients with cystic fibrosis. Pediatr Res 8:899

doi: 10.1203/00006450-197411000-00031

Brunton CE (1933) The influence of foodstuffs on the rate of urinary acid excretion. J Physiol 78:65–79. https://doi.org/10.1113/jphysiol.1933.sp002986

doi: 10.1113/jphysiol.1933.sp002986 pubmed: 16994404 pmcid: 1394897

Chen L, Chou CL, Knepper MA (2021) A comprehensive map of mRNAs and their isoforms across all 14 renal tubule segments of mouse. J Am Soc Nephrol. https://doi.org/10.1681/ASN.2020101406

doi: 10.1681/ASN.2020101406 pubmed: 34921111 pmcid: 8638405

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Paunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA (2017) Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq. Proc Natl Acad Sci U S A 114:E9989–E9998. https://doi.org/10.1073/pnas.1710964114

doi: 10.1073/pnas.1710964114 pubmed: 29089413 pmcid: 5699061

Cheng CY, Chu JY, Chow BK (2011) Central and peripheral administration of secretin inhibits food intake in mice through the activation of the melanocortin system. Neuropsychopharmacology 36:459–471. https://doi.org/10.1038/npp.2010.178

doi: 10.1038/npp.2010.178 pubmed: 20927047

Chey WY, Chang TM (2003) Secretin, 100 years later. J Gastroenterol 38:1025–1035. https://doi.org/10.1007/s00535-003-1235-3

doi: 10.1007/s00535-003-1235-3 pubmed: 14673718

Chey WY, Kim MS, Lee KY, Chang TM (1981) Secretin is an enterogastrone in the dog. Am J Physiol 240:G239-244. https://doi.org/10.1152/ajpgi.1981.240.3.G239

doi: 10.1152/ajpgi.1981.240.3.G239 pubmed: 6782895

Chey WY, Konturek SJ (1982) Plasma secretion and pancreatic secretion in response to liver extract meal with varied pH and exogenous secretin in the dog. J Physiol 324:263–272. https://doi.org/10.1113/jphysiol.1982.sp014111

doi: 10.1113/jphysiol.1982.sp014111 pubmed: 7097601 pmcid: 1250704

Chu JY, Chung SC, Lam AK, Tam S, Chung SK, Chow BK (2007) Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption. Mol Cell Biol 27:2499–2511. https://doi.org/10.1128/MCB.01088-06 . (MCB.01088-06 [pii])

doi: 10.1128/MCB.01088-06 pubmed: 17283064 pmcid: 1899889

Chu JY, Lee LT, Lai CH, Vaudry H, Chan YS, Yung WH, Chow BK (2009) Secretin as a neurohypophysial factor regulating body water homeostasis. Proc Natl Acad Sci U S A 106:15961–15966. https://doi.org/10.1073/pnas.0903695106

doi: 10.1073/pnas.0903695106 pubmed: 19805236 pmcid: 2747226

Davis RJ, Page KJ, Dos Santos Cruz GJ, Harmer DW, Munday PW, Williams SJ, Picot J, Evans TJ, Sheldrick RL, Coleman RA, Clark KL (2004) Expression and functions of the duodenal peptide secretin and its receptor in human lung. Am J Respir Cell Mol Biol 31:302–308. https://doi.org/10.1165/rcmb.2004-0035OC

doi: 10.1165/rcmb.2004-0035OC pubmed: 15191914

Faichney A, Chey WY, Kim YC, Lee KY, Kim MS, Chang TM (1981) Effect of sodium oleate on plasma secretin concentration and pancreatic secretion in dog. Gastroenterology 81:458–462

doi: 10.1016/0016-5085(81)90596-5 pubmed: 7250635

Ferdaus MZ, Terker AS, Koumangoye R, Delpire E (2022) KCC3a, a strong candidate pathway for K(+) loss in alkalemia. Front Cell Dev Biol 10:931326. https://doi.org/10.3389/fcell.2022.931326

doi: 10.3389/fcell.2022.931326 pubmed: 35874803 pmcid: 9301082

Ferdaus MZ, Terker AS, Koumangoye R, Wall SM, Delpire E (2023) Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells. Am J Physiol Cell Physiol 324:C1171-c1178. https://doi.org/10.1152/ajpcell.00094.2023

doi: 10.1152/ajpcell.00094.2023 pubmed: 37036298

Gardner JD, Jensen RT (1986) Receptors and cell activation associated with pancreatic enzyme secretion. Annu Rev Physiol 48:103–117. https://doi.org/10.1146/annurev.ph.48.030186.000535

doi: 10.1146/annurev.ph.48.030186.000535 pubmed: 2423019

Giesecke T, Himmerkus N, Leipziger J, Bleich M, Koshimizu TA, Fahling M, Smorodchenko A, Shpak J, Knappe C, Isermann J, Ayasse N, Kawahara K, Schmoranzer J, Gimber N, Paliege A, Bachmann S, Mutig K (2019) Vasopressin increases urinary acidification via V1a receptors in collecting duct intercalated cells. J Am Soc Nephrol 30:946–961. https://doi.org/10.1681/ASN.2018080816

doi: 10.1681/ASN.2018080816 pubmed: 31097611 pmcid: 6551786

Gifford JD, Ware MW, Luke RG, Galla JH (1993) HCO3- transport in rat CCD: rapid adaptation by in vivo but not in vitro alkalosis. Am J Physiol 264:F435-440. https://doi.org/10.1152/ajprenal.1993.264.3.F435

doi: 10.1152/ajprenal.1993.264.3.F435 pubmed: 8456957

Gilliam-Vigh H, Jorsal T, Nielsen SW, Forman JL, Pedersen J, Poulsen SS, Vilsbøll T, Knop FK (2023) Expression of secretin and its receptor along the intestinal tract in type 2 diabetes patients and healthy controls. J Clin Endocrinol Metab. https://doi.org/10.1210/clinem/dgad372

doi: 10.1210/clinem/dgad372 pubmed: 37335970

Good DW (1993) The thick ascending limb as a site of renal bicarbonate reabsorption. Semin Nephrol 13:225–235

pubmed: 8465120

Greenberg GR, Domschke S, Domschke W, Rösch W, Bloom SR (1979) Effect of low dose secretin and caerulein on pure pancreatic bicarbonate secretion and plasma secretin in man. Acta Hepatogastroenterol (Stuttg) 26:478–481

pubmed: 549430

Gunnes P, Rasmussen K (1986) Haemodynamic effects of pharmacological doses of secretin in patients with impaired left ventricular function. Eur Heart J 7:146–149. https://doi.org/10.1093/oxfordjournals.eurheartj.a062037

doi: 10.1093/oxfordjournals.eurheartj.a062037 pubmed: 3699051

Gunnes P, Waldum HL, Rasmussen K, Ostensen H, Burhol PG (1983) Cardiovascular effects of secretin infusion in man. Scand J Clin Lab Invest 43:637–642

doi: 10.3109/00365518309168843 pubmed: 6658378

Gyr K, Beglinger C, Fried M, Grötzinger U, Kayasseh L, Stalder GA, Girard J (1984) Plasma secretin and pancreatic response to various stimulants including a meal. Am J Physiol 246:G535-542. https://doi.org/10.1152/ajpgi.1984.246.5.G535

doi: 10.1152/ajpgi.1984.246.5.G535 pubmed: 6720952

Hansen NM, Berg P, Rix M, Pareek M, Leipziger J, Kamper AL, Astrup A, Vaarby Sorensen M, Salomo L (2023) The New Nordic Renal Diet induces a pronounced reduction of urine acid excretion and uremic toxins in chronic kidney disease patients (Stage 3 and 4). J Ren Nutr 33:412–419. https://doi.org/10.1053/j.jrn.2022.09.010

doi: 10.1053/j.jrn.2022.09.010 pubmed: 36195272

Jones HB (1851) Contributions to the chemistry of the urine; on the variations in the alkaline and earthy phosphates in the healthy state, and on the alkalescence of the urine from fixed alkali. Proc R Soc Lond 5:5561–562. https://doi.org/10.1098/rspl.1843.0054

Henriksen JH, Schaffalitzky de Muckadell OB (2002) Secretin–the first hormone. Ugeskr Laeger 164:320–325

pubmed: 11816326

Hirst BH (2004) Secretin and the exposition of hormonal control. J Physiol 560:339. https://doi.org/10.1113/jphysiol.2004.073056

doi: 10.1113/jphysiol.2004.073056 pubmed: 15308687 pmcid: 1665254

Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S (1991) Molecular cloning and expression of a cDNA encoding the secretin receptor. Embo j 10:1635–1641. https://doi.org/10.1002/j.1460-2075.1991.tb07686.x

doi: 10.1002/j.1460-2075.1991.tb07686.x pubmed: 1646711 pmcid: 452832

Jensen RT, Charlton CG, Adachi H, Jones SW, O’Donohue TL, Gardner JD (1983) Use of 125I-secretin to identify and characterize high-affinity secretin receptors on pancreatic acini. Am J Physiol 245:G186-195. https://doi.org/10.1152/ajpgi.1983.245.2.G186

doi: 10.1152/ajpgi.1983.245.2.G186 pubmed: 6309017

Kaplan EL, Peskin GW, Deveney C, Way L, Jaffe B (1974) Ulcer disease, metabolic alkalosis and hyperparathyroidism: a mechanism of interrelationship? Ann Surg 180:549–557. https://doi.org/10.1097/00000658-197410000-00019

doi: 10.1097/00000658-197410000-00019 pubmed: 4416767 pmcid: 1344139

Kirkegaard P, Skov Olsen P, Seier Poulsen S, Holst JJ, Schaffalitzky de Muckadell OB, Christiansen J (1984) Effect of secretin and glucagon on Brunner’s gland secretion in the rat. Gut 25:264–268. https://doi.org/10.1136/gut.25.3.264

doi: 10.1136/gut.25.3.264 pubmed: 6698442 pmcid: 1432278

Kleibeuker JH, Eysselein VE, Maxwell VE, Walsh JH (1984) Role of endogenous secretin in acid-induced inhibition of human gastric function. J Clin Invest 73:526–532. https://doi.org/10.1172/jci111239

doi: 10.1172/jci111239 pubmed: 6699175 pmcid: 425044

Kofod H (1986) Secretin N-terminal hexapeptide potentiates insulin release in mouse islets. Regul Pept 15:229–237. https://doi.org/10.1016/0167-0115(86)90064-9

doi: 10.1016/0167-0115(86)90064-9 pubmed: 3538223

Kopin AS, Wheeler MB, Leiter AB (1990) Secretin: structure of the precursor and tissue distribution of the mRNA. Proc Natl Acad Sci U S A 87:2299–2303. https://doi.org/10.1073/pnas.87.6.2299

doi: 10.1073/pnas.87.6.2299 pubmed: 2315322 pmcid: 53674

Kunzelmann K, Schreiber R, Hadorn HB (2017) Bicarbonate in cystic fibrosis. J Cyst Fibros 16:653–662. https://doi.org/10.1016/j.jcf.2017.06.005

doi: 10.1016/j.jcf.2017.06.005 pubmed: 28732801

Laurila S, Rebelos E, Honka MJ, Nuutila P (2021) Pleiotropic effects of secretin: a potential drug candidate in the treatment of obesity? Front Endocrinol (Lausanne) 12:737686. https://doi.org/10.3389/fendo.2021.737686

doi: 10.3389/fendo.2021.737686 pubmed: 34671320

Laurila S, Rebelos E, Lahesmaa M, Sun L, Schnabl K, Peltomaa TM, Klén R, UD M, Honka MJ, Eskola O, Kirjavainen AK, Nummenmaa L, Klingenspor M, Virtanen KA, Nuutila P (2022) Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function. Am J Physiol Endocrinol Metab 322:E54-e62. https://doi.org/10.1152/ajpendo.00260.2021

doi: 10.1152/ajpendo.00260.2021 pubmed: 34806426

Laurila S, Sun L, Lahesmaa M, Schnabl K, Laitinen K, Klén R, Li Y, Balaz M, Wolfrum C, Steiger K, Niemi T, Taittonen M, UD M, Välikangas T, Elo LL, Eskola O, Kirjavainen AK, Nummenmaa L, Virtanen KA, Klingenspor M, Nuutila P (2021) Secretin activates brown fat and induces satiation. Nat Metab 3:798–809. https://doi.org/10.1038/s42255-021-00409-4

doi: 10.1038/s42255-021-00409-4 pubmed: 34158656

Lee KY, Chey WY, Tai HH (1978) Roles of the vagus in endogenous release of secretin and exocrine pancreatic secretion in dog. Adv Exp Med Biol 106:211–216. https://doi.org/10.1007/978-1-4684-7248-6_27

doi: 10.1007/978-1-4684-7248-6_27 pubmed: 31072

Lee MG, Ohana E, Park HW, Yang D, Muallem S (2012) Molecular mechanism of pancreatic and salivary gland fluid and HCO3 secretion. Physiol Rev 92:39–74. https://doi.org/10.1152/physrev.00011.2011

doi: 10.1152/physrev.00011.2011 pubmed: 22298651

Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, UD M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O’Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M (2018) Secretin-activated brown fat mediates prandial thermogenesis to induce satiation. Cell 175:1561-1574.e1512. https://doi.org/10.1016/j.cell.2018.10.016

doi: 10.1016/j.cell.2018.10.016 pubmed: 30449620

Llanos OL, Konturek SJ, Rayford PL, Thompson JC (1977) Pancreatic bicarbonate, serum gastrin, and secretin responses to meals varying in pH. Am J Physiol 233:E41-46. https://doi.org/10.1152/ajpendo.1977.233.1.E41

doi: 10.1152/ajpendo.1977.233.1.E41 pubmed: 18021

Marchand GR, Ott CE, Lang FC, Greger RF, Knox FG (1977) Effect of secretin on renal blood flow, interstitial pressure, and sodium excretion. Am J Physiol 232:F147-151. https://doi.org/10.1152/ajprenal.1977.232.2.F147

doi: 10.1152/ajprenal.1977.232.2.F147 pubmed: 842636

Meyer JH, Way LW, Grossman MI (1970) Pancreatic response to acidification of various lengths of proximal intestine in the dog. Am J Physiol 219:971–977. https://doi.org/10.1152/ajplegacy.1970.219.4.971

doi: 10.1152/ajplegacy.1970.219.4.971 pubmed: 5459499

Miller TA, Llanos OL, Swierczek JS, Rayford PL, Thompson JC (1978) Concentrations of gastrin and secretin in the alimentary tract of the cat. Surgery 83:90–93

pubmed: 619477

Modvig IM, Andersen DB, Grunddal KV, Kuhre RE, Martinussen C, Christiansen CB, Ørskov C, Larraufie P, Kay RG, Reimann F, Gribble FM, Hartmann B, Bojsen-Møller KN, Madsbad S, Wewer Albrechtsen NJ, Holst JJ (2020) Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine. Int J Obes (Lond) 44:1859–1871. https://doi.org/10.1038/s41366-020-0541-7

doi: 10.1038/s41366-020-0541-7 pubmed: 32015474

Mutt V, Jorpes JE, Magnusson S (1970) Structure of porcine secretin. The amino acid sequence. Eur J Biochem 15:513–519. https://doi.org/10.1111/j.1432-1033.1970.tb01034.x

doi: 10.1111/j.1432-1033.1970.tb01034.x pubmed: 5465996

Nicholls DP, Riley M, Elborn JS, Stanford CF, Shaw C, McKillop JM, Buchanan KD (1992) Regulatory peptides in the plasma of patients with chronic cardiac failure at rest and during exercise. Eur Heart J 13:1399–1404. https://doi.org/10.1093/oxfordjournals.eurheartj.a060073

doi: 10.1093/oxfordjournals.eurheartj.a060073 pubmed: 1396815

Nilsson A, Carlquist M, Jörnvall H, Mutt V (1980) Isolation and characterization of chicken secretin. Eur J Biochem 112:383–388. https://doi.org/10.1111/j.1432-1033.1980.tb07216.x

doi: 10.1111/j.1432-1033.1980.tb07216.x pubmed: 7460928

Oliver G, Schäfer EA (1895) The physiological effects of extracts of the suprarenal capsules. J Physiol 18:230–276. https://doi.org/10.1113/jphysiol.1895.sp000564

doi: 10.1113/jphysiol.1895.sp000564 pubmed: 16992252 pmcid: 1514629

Polak JM, Coulling I, Bloom S, Pearse AG (1971) Immunofluorescent localization of secretin and enteroglucagon in human intestinal mucosa. Scand J Gastroenterol 6:739–744. https://doi.org/10.3109/00365527109179946

doi: 10.3109/00365527109179946 pubmed: 4945081

Poulsen SB, Marin De Evsikova C, Murali SK, Praetorius J, Chern Y, Fenton RA, Rieg T (2018) Adenylyl cyclase 6 is required for maintaining acid-base homeostasis. Clin Sci (Lond) 132:1779–1796. https://doi.org/10.1042/cs20180060

doi: 10.1042/cs20180060 pubmed: 29941522

Procino G, Milano S, Carmosino M, Barbieri C, Nicoletti MC, Li JH, Wess J, Svelto M (2014) Combination of secretin and fluvastatin ameliorates the polyuria associated with X-linked nephrogenic diabetes insipidus in mice. Kidney Int 86:127–138. https://doi.org/10.1038/ki.2014.10 . (S0085-2538(15)30238-6 [pii])

doi: 10.1038/ki.2014.10 pubmed: 24522493 pmcid: 4080339

Rhodes RA, Tai HH, Chey WY (1978) Impairment of secretin release in celiac sprue. Am J Dig Dis 23:833–839. https://doi.org/10.1007/bf01079794

doi: 10.1007/bf01079794 pubmed: 30279

Roth BL, Beinfeld MC, Howlett AC (1984) Secretin receptors on neuroblastoma cell membranes: characterization of 125I-labeled secretin binding and association with adenylate cyclase. J Neurochem 42:1145–1152. https://doi.org/10.1111/j.1471-4159.1984.tb12723.x

doi: 10.1111/j.1471-4159.1984.tb12723.x pubmed: 6321661

Schaffalitzky de Muckadell OB, Fahrenkrug J (1978) Secretion pattern of secretin in man: regulation by gastric acid. Gut 19:812–818. https://doi.org/10.1136/gut.19.9.812

doi: 10.1136/gut.19.9.812 pubmed: 30682 pmcid: 1412177

Soloway RD, Clark ML, Powell KM, Senior JR, Brooks FP (1972) Effects of secretin and bile salt infusions on canine bile composition and flow. Am J Physiol 222:681–686. https://doi.org/10.1152/ajplegacy.1972.222.3.681

doi: 10.1152/ajplegacy.1972.222.3.681 pubmed: 5022680

Spoletini G, Fitch G, Gillgrass L, Etherington C, Clifton I, Peckham DG (2022) Urinary bicarbonate and metabolic alkalosis during exacerbations in cystic fibrosis. ERJ Open Res 8(2):00669–2021. https://doi.org/10.1183/23120541.00669-2021

Straus E, Johnson GF, Yalow RS (1977) Canine Zollinger-Ellison syndrome. Gastroenterology 72:380–381

doi: 10.1016/S0016-5085(77)80131-5 pubmed: 187526

Teufel M, Luik G, Niessen KH (1986) Gastrin, secretin, VIP and motilin in children with mucoviscidosis and Crohn disease. Monatsschr Kinderheilkd 134:132–137

pubmed: 3702884

Tomoda A, Yamanaka S, Kawai H, Itoh H, Katsumata M, Minami M, Hashimoto T, Tanii H, Hashimoto K (1995) Variation of urinary pH and bicarbonate concentrations of students in metropolitan and rural areas of Japan. Arch Environ Health 50:457–461. https://doi.org/10.1080/00039896.1995.9935983

doi: 10.1080/00039896.1995.9935983 pubmed: 8572725

Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M (2019) cAMP stimulates SLC26A3 activity in human colon by a CFTR-Dependent mechanism that does not require CFTR activity. Cell Mol Gastroenterol Hepatol 7:641–653. https://doi.org/10.1016/j.jcmgh.2019.01.002

doi: 10.1016/j.jcmgh.2019.01.002 pubmed: 30659943 pmcid: 6438990

Varasteh Kia M, Barone S, McDonough AA, Zahedi K, Xu J, Soleimani M (2018) Downregulation of the Cl-/HCO3-exchanger pendrin in kidneys of mice with cystic fibrosis: role in the pathogenesis of metabolic alkalosis. Cell Physiol Biochem 45:1551–1565. https://doi.org/10.1159/000487691

doi: 10.1159/000487691 pubmed: 29482189

Viteri AL, Poppell JW, Lasater JM, Dyck WP (1975) Renal response to secretin. J Appl Physiol 38:661–664

doi: 10.1152/jappl.1975.38.4.661 pubmed: 237865

Vitzthum H, Koch M, Eckermann L, Svendsen SL, Berg P, Hübner CA, Wagner CA, Leipziger J, Meyer-Schwesinger C, Ehmke H (2023) The AE4 transporter mediates kidney acid-base sensing. Nat Commun 14:3051. https://doi.org/10.1038/s41467-023-38562-x

doi: 10.1038/s41467-023-38562-x pubmed: 37236964 pmcid: 10220024

Wall SM, Lazo-Fernandez Y (2015) The role of pendrin in renal physiology. Annu Rev Physiol 77:363–378. https://doi.org/10.1146/annurev-physiol-021014-071854

doi: 10.1146/annurev-physiol-021014-071854 pubmed: 25668022

Zaw AM, Sekar R, Mak SOK, Law HKW, Chow BKC (2019) Loss of secretin results in systemic and pulmonary hypertension with cardiopulmonary pathologies in mice. Sci Rep 9:14211. https://doi.org/10.1038/s41598-019-50634-x

doi: 10.1038/s41598-019-50634-x pubmed: 31578376 pmcid: 6775067

Zhang F, Mak SOK, Liu Y, Ke Y, Rao F, Yung WH, Zhang L, Chow BKC (2022) Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration. Curr Biol 32:4832-4841.e4835. https://doi.org/10.1016/j.cub.2022.09.037

doi: 10.1016/j.cub.2022.09.037 pubmed: 36220076

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Auteurs

Peder Berg (P)

Samuel L Svendsen (SL)

Niklas Ayasse (N)

Mads Vaarby Sorensen (MV)

Jens Leipziger (J)

Classifications MeSH