POMC Neuron BBSome Regulation of Body Weight is Independent of its Ciliary Function.

Bardet-Biedl syndrome proteins energy balance hypothalamus proopiomelanocortin neurons

Journal

Function (Oxford, England)
ISSN: 2633-8823
Titre abrégé: Function (Oxf)
Pays: England
ID NLM: 101770668

Informations de publication

Date de publication:
2024
Historique:
received: 09 10 2023
revised: 05 12 2023
accepted: 18 12 2023
medline: 15 1 2024
pubmed: 15 1 2024
entrez: 15 1 2024
Statut: epublish

Résumé

The BBSome, a complex of several Bardet-Biedl syndrome (BBS) proteins including BBS1, has emerged as a critical regulator of energy homeostasis. Although the BBSome is best known for its involvement in cilia trafficking, through a process that involve BBS3, it also regulates the localization of cell membrane receptors underlying metabolic regulation. Here, we show that inducible

Identifiants

DOI: 10.1093/function/zqad070 PMID: 38223458 PMC: PMC10787280
pubmed: 38223458
doi: 10.1093/function/zqad070
pii: zqad070
pmc: PMC10787280
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

zqad070

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of American Physiological Society.

Déclaration de conflit d'intérêts

The authors have no conflict of interest relevant to this study.

Auteurs

Deng-Fu Guo (DF)

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Veterans Affairs Health Care System, Iowa City, IA 52242, USA.

Paul A Williams (PA)

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Connor Laule (C)

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Charles Seaby (C)

Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Qihong Zhang (Q)

Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Val C Sheffield (VC)

Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

Kamal Rahmouni (K)

Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Veterans Affairs Health Care System, Iowa City, IA 52242, USA.
Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Obesity Research and Education Initiative, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
ORCID: 0000-0001-5136-6748

Classifications MeSH