Photopharmacology of Protease Inhibitors: Current Status and Perspectives.
Azobenzenes
photopharmacology
photoprotecting groups
photoswitches
proteases
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
15 Jan 2024
15 Jan 2024
Historique:
revised:
10
01
2024
received:
30
11
2023
accepted:
15
01
2024
medline:
15
1
2024
pubmed:
15
1
2024
entrez:
15
1
2024
Statut:
aheadofprint
Résumé
Proteases are involved in many essential biological processes. Dysregulation of their activity underlies a wide variety of human diseases. Photopharmacology, as applied on various classes of proteins, has the potential to assist protease research by enabling spatiotemporal control of protease activity. Moreover, it may be used to decrease side-effects of protease-targeting drugs. In this review, we discuss the current status of the chemical design of photoactivatable proteases inhibitors and their biological application. Additionally, we give insight into future possibilities for further development of this field of research.
Identifiants
pubmed: 38224181
doi: 10.1002/chem.202303999
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202303999Informations de copyright
© 2024 Wiley-VCH GmbH.