Scalable plasma and digital cognitive markers for diagnosis and prognosis of Alzheimer's disease and related dementias.
Alzheimer's disease
blood-based biomarkers
diagnosis
digital cognitive assessment
disease monitoring
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
11
12
2023
received:
01
09
2023
accepted:
16
12
2023
medline:
18
3
2024
pubmed:
15
1
2024
entrez:
15
1
2024
Statut:
ppublish
Résumé
With emergence of disease-modifying therapies, efficient diagnostic pathways are critically needed to identify treatment candidates, evaluate disease severity, and support prognosis. A combination of plasma biomarkers and brief digital cognitive assessments could provide a scalable alternative to current diagnostic work-up. We examined the accuracy of plasma biomarkers and a 10-minute supervised tablet-based cognitive assessment (Tablet-based Cognitive Assessment Tool Brain Health Assessment [TabCAT-BHA]) in predicting amyloid β positive (Aβ+) status on positron emission tomography (PET), concurrent disease severity, and functional decline in 309 older adults with subjective cognitive impairment (n = 49), mild cognitive impairment (n = 159), and dementia (n = 101). Combination of plasma pTau181, Aβ42/40, neurofilament light (NfL), and TabCAT-BHA was optimal for predicting Aβ-PET positivity (AUC = 0.962). Whereas NfL and TabCAT-BHA optimally predicted concurrent disease severity, combining these with pTau181 and glial fibrillary acidic protein was most accurate in predicting functional decline. Combinations of plasma and digital cognitive markers show promise for scalable diagnosis and prognosis of ADRD. The need for cost-efficient diagnostic and prognostic markers of AD is urgent. Plasma and digital cognitive markers provide complementary diagnostic contributions. Combination of these markers holds promise for scalable diagnosis and prognosis. Future validation in community cohorts is needed to inform clinical implementation.
Identifiants
pubmed: 38224278
doi: 10.1002/alz.13686
pmc: PMC10942726
mid: NIHMS1965127
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2089-2101Subventions
Organisme : NIA NIH HHS
ID : P30AG062422
Pays : United States
Organisme : Alzheimer's Association
ID : AARF-21-851552
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : R35 AG072362
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG059888
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS128913
Pays : United States
Organisme : NINDS NIH HHS
ID : UG3 NS105557
Pays : United States
Organisme : NIA NIH HHS
ID : R35AG072362
Pays : United States
Informations de copyright
© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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