Simultaneous melanomas in the setting of multiple primary melanomas.
Journal
Melanoma research
ISSN: 1473-5636
Titre abrégé: Melanoma Res
Pays: England
ID NLM: 9109623
Informations de publication
Date de publication:
15 Jan 2024
15 Jan 2024
Historique:
medline:
15
1
2024
pubmed:
15
1
2024
entrez:
15
1
2024
Statut:
aheadofprint
Résumé
It is estimated that about 1-13% of melanoma patients will develop multiple primary melanomas. Although the occurrence of subsequent tumors has been described during the last few years, the development of simultaneous melanomas has not yet been extensively studied. We reviewed our registries to identify patients with multiple primary melanomas. We studied epidemiological, clinical, and histological characteristics of patients who were diagnosed with simultaneous melanomas and compared them with those of patients who developed non-synchronous multiple primary melanomas. As simultaneous were defined subsequent melanomas that were diagnosed either at the same visit or within a time-period of maximum of 1 month. Between 2000 and 2020, 2500 patients were diagnosed with melanoma at Andreas Syggros Hospital. 86 (3.4%) patients presented multiple primary melanomas and among them, 35 (40.7%) developed simultaneous melanomas. Patients with simultaneous melanomas developed more frequently more than 2 tumors. First tumors of patients with non-synchronous melanomas were significantly thicker than second tumors while those of patients with simultaneous melanomas did not differ significantly. Slight differences in the tumor localization, staging and histologic type were observed between the two groups. However significant differences were ascertained between first and second tumors in both groups. Simultaneous melanomas occupy an important proportion of multiple primary melanomas, affecting a non-negligible number of patients. Slight differences between simultaneous and non-synchronous multiple primary melanomas seem to define a distinct subcategory of multiple primary melanomas.
Identifiants
pubmed: 38224405
doi: 10.1097/CMR.0000000000000954
pii: 00008390-990000000-00125
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Références
Titus-Ernstoff L, Perry AE, Spencer SK, Gibson J, Ding J, Cole B, et al. Multiple primary melanoma: two-year results from a population-based study. Arch Dermatol 2006; 142:433–438.
Manganoni AM, Farisoglio C, Tucci G, Facchetti F, Calzavara Pinton PG. The importance of self-examination in the earliest diagnosis of multiple primary cutaneous melanomas: a report of 47 cases. J Eur Acad Dermatol Venereol 2007; 21:1333–1336.
Vecchiato A, Pasquali S, Menin C, Montesco MC, Alaibac M, Mocellin S, et al. Histopathopathological characteristics of subsequent melanomas in patients with multiple primary melanomas. J Eur Acad Dermatol Venereol 2014; 28:58–64.
Murali R, Goumas C, Kricker A, From L, Busam KJ, Begg CB, et al.; GEM Study Group. Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas. Ann Surg Oncol 2012; 19:1024–1033.
Muller C, Wendt J, Rauscher S, Sunder-Plassmann R, Richtig E, Fae I, et al. Risk factors of subsequent primary melanomas in Austria. JAMA Dermatol 2019; 155:188–195.
Helgadottir H, Issakson K, Fritz I, et al. Multiple primary melanoma trends over five decades: a nationwide population-based study. J Natl Cancer Inst 2021; 113:318–328.
Savoia P, Osella-Abate S, Deboli T, Marenco F, Stroppiana E, Novelli M, et al. Clinical and prognostic reports from 270 patients with multiple primary melanomas: a 34-year single-institution study. J Eur Acad Dermatol Venereol 2012; 26:882–888.
Menzies S, Barry R, Ormond P. Multiple primary melanoma: a single center retrospective review. Melanoma Res 2017; 27:638–640.
Moore MM, Geller AC, Warton EM, Schwalbe J, Asgari MM. Multiple primary melanomas among 16,570 patients with melanoma diagnosed at Kaiser Permanente Northern California 1996 to 2011. J Am Acad Dermatol 2015; 73:630–636.
Colombino M, Sini M, Lissia A, De Giorgi V, Stanganelli I, Ayala F, et al.; Italian Melanoma Intergroup (IMI). Discrepant alterations in main candidate genes among multiple primary melanomas. J Transl Med 2014; 12:117.
Palacios-Diaz RD, de Unamuno-Bustos B, Abril-Perez C, Pozuelo-Ruiz M, Sánchez-Arraez J, Torres-Navarro I, et al. Multiple primary melanomas: retrospective review in a tertiary care hospital. J Clin Med 2022; 11:2355.
Hwa C, Price LS, Belitskaya-Levy I, Ma MW, Shapiro RL, Berman RS, et al. Single versus multiple primary melanomas: old questions and new answers. Cancer 2012; 118:4184–4192.
Di Fronzo LA, Wanek LA, Morton DL. Earlier diagnosis of second primary melanoma confirms the benefit of patient education and routine postoperative follow-up. Cancer 2001; 91:1524.
De Giorgi V, Rossari S, Papi F, Gori A, Alfaioli B, Grazzini M, et al. Multiple primary melanoma: The impact of atypical nevi and follow up. Br J Dermatol 2010; 163:1319–1322.
Adler NR, Kelly JW, Haydon A, McLean CA, Mar VJ. Clinicopathological characteristics and prognosis of patients with multiple primary melanomas. Br J Dermatol 2018; 178:e44–e45.