Effects of hypoxia in the diabetic corneal stroma microenvironment.

Corneal wound healing Diabetes mellitus Diabetic keratopathy Heat shock proteins Hypoxia Mitochondrial enzymes Oxidative stress

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
13 Jan 2024
Historique:
received: 01 10 2023
revised: 15 12 2023
accepted: 12 01 2024
medline: 16 1 2024
pubmed: 16 1 2024
entrez: 15 1 2024
Statut: aheadofprint

Résumé

Corneal dysfunctions associated with Diabetes Mellitus (DM), termed diabetic keratopathy (DK), can cause impaired vision and/or blindness. Hypoxia affects both Type 1 (T1DM) and Type 2 (T2DM) surprisingly, the role of hypoxia in DK is unexplored. The aim of this study was to examine the impact of hypoxia in vitro on primary human corneal stromal cells derived from Healthy (HCFs), and diabetic (T1DMs and T2DMs) subjects, by exposing them to normoxic (21% O

Identifiants

DOI: 10.1016/j.exer.2024.109790 PMID: 38224848
pubmed: 38224848
pii: S0014-4835(24)00011-3
doi: 10.1016/j.exer.2024.109790
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109790

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Purnima Sharma (P)

North Texas Eye Research Institute, University of North Texas Health Science Center, 3430 Camp Bowie Blvd, Fort Worth, TX, 76107, USA; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, 3430 Camp Bowie Blvd, Fort Worth, TX, 76107, USA. Electronic address: purnima.sharma@unthsc.edu.

Jian-Xing Ma (JX)

Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.

Dimitrios Karamichos (D)

North Texas Eye Research Institute, University of North Texas Health Science Center, 3430 Camp Bowie Blvd, Fort Worth, TX, 76107, USA; Department of Pharmaceutical Sciences, University of North Texas Health Science Center, 3430 Camp Bowie Blvd, Fort Worth, TX, 76107, USA; Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, 3430 Camp Bowie Blvd, Fort Worth, TX, 76107, USA. Electronic address: Dimitrios.Karamichos@unthsc.edu.

Classifications MeSH