LINC complex protein nesprin-2 has pro-apoptotic activity via Bcl-2 family proteins.

Journal

Cell death discovery
ISSN: 2058-7716
Titre abrégé: Cell Death Discov
Pays: United States
ID NLM: 101665035

Informations de publication

Date de publication:
15 Jan 2024
Historique:
received: 21 09 2023
accepted: 06 12 2023
revised: 13 11 2023
medline: 16 1 2024
pubmed: 16 1 2024
entrez: 15 1 2024
Statut: epublish

Résumé

The apoptotic intrinsic pathway is initiated by perforation of the mitochondrial outer membrane by the effector pro-apoptotic proteins of the Bcl-2 family, Bax and Bak. Bax and Bak need to be activated, a process facilitated by the action of BH3-only pro-apoptotic members of the Bcl-2 family. The latter either directly activates the effector proteins or antagonizes the action of pro-survival Bcl-2 family members such as Bcl-x

Identifiants

DOI: 10.1038/s41420-023-01763-w PMID: 38225256
pubmed: 38225256
doi: 10.1038/s41420-023-01763-w
pii: 10.1038/s41420-023-01763-w
doi:

Types de publication

Journal Article

Langues

eng

Pagination

29

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM136403
Pays : United States

Informations de copyright

© 2024. The Author(s).

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Auteurs

Liora Lindenboim (L)

Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.

Hila Zohar (H)

Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.

Gregg G Gundersen (GG)

Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

Howard J Worman (HJ)

Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.
Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA.

Reuven Stein (R)

Department of Neurobiology, School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel. reuvens@tauex.tau.ac.il.
ORCID: 0000-0002-7166-6542

Classifications MeSH