Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy.
Biological sciences
Natural sciences
Physiology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
19 Jan 2024
19 Jan 2024
Historique:
received:
16
06
2023
revised:
16
11
2023
accepted:
01
12
2023
medline:
16
1
2024
pubmed:
16
1
2024
entrez:
16
1
2024
Statut:
epublish
Résumé
Smooth muscle cell (SMC) accumulation is central to the pathogenesis of elastin-defective arterial diseases, including supravalvular aortic stenosis (SVAS). We previously demonstrated that elastin insufficiency activates Notch signaling in aortic SMCs. Activation of Notch is catalyzed by the enzyme gamma-secretase, but the role of catalytic subunits presenilin (PSEN)-1 or PSEN-2 in elastin aortopathy is not defined. Genetic approaches reveal that endothelial cell-specific
Identifiants
pubmed: 38226162
doi: 10.1016/j.isci.2023.108636
pii: S2589-0042(23)02713-X
pmc: PMC10788461
doi:
Types de publication
Journal Article
Langues
eng
Pagination
108636Informations de copyright
© 2023 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.