Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway.

Cardiotoxicity Carfilzomib Chemotherapy Inflammation Oxyphenbutazone

Journal

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
ISSN: 1319-0164
Titre abrégé: Saudi Pharm J
Pays: Saudi Arabia
ID NLM: 9705695

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 05 11 2023
accepted: 16 12 2023
medline: 16 1 2024
pubmed: 16 1 2024
entrez: 16 1 2024
Statut: ppublish

Résumé

Carfilzomib (CFZ), a chemotherapeutic agent used for multiple myeloma treatments reported to cause high incidence of cardiac events either new onset and/or exacerbate formerly diagnosed heart failure with ventricular and myocardial dysfunction.

Identifiants

DOI: 10.1016/j.jsps.2023.101926 PMID: 38226350 PMC: PMC10788627
pubmed: 38226350
doi: 10.1016/j.jsps.2023.101926
pii: S1319-0164(23)00421-8
pmc: PMC10788627
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101926

Informations de copyright

© 2023 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Faisal Imam (F)

Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Muhammad Afzal (M)

Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia.

Nehmat Ghaboura (N)

Pharmacy Practice Department, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia.

Khalid Saad Alharbi (K)

Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia.

Imran Kazmi (I)

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Samiyah Alshehri (S)

Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.

Sana Saeed Alqarni (S)

Medical Laboratory Science Department, College of Applied Medical Sciences,King Saud University, Riyadh, Saudi Arabia.

Emine Guven (E)

Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA, USA.

Classifications MeSH