The emerging roles of histone demethylases in cancers.
Cancers
Complex therapy strategies
Histone demethylases
Inhibitors
Journal
Cancer metastasis reviews
ISSN: 1573-7233
Titre abrégé: Cancer Metastasis Rev
Pays: Netherlands
ID NLM: 8605731
Informations de publication
Date de publication:
16 Jan 2024
16 Jan 2024
Historique:
received:
26
04
2022
accepted:
05
12
2023
medline:
16
1
2024
pubmed:
16
1
2024
entrez:
16
1
2024
Statut:
aheadofprint
Résumé
Modulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantial clinical potential for the therapy of diseases, including cancer and other disorders. The present study aimed to provide a comprehensive introduction to the enzymology of histone demethylases, as well as their cancerous roles, molecular mechanisms, therapeutic possibilities, and challenges for targeting them, in order to advance drug design for clinical therapy and highlight new insight into the mechanisms of these enzymes in cancer. A series of clinical trials have been performed to explore potential roles of histone demethylases in several cancer types. Numerous targeted inhibitors associated with immunotherapy, chemotherapy, radiotherapy, and targeted therapy have been used to exert anticancer functions. Future studies should evaluate the dynamic transformation of histone demethylases leading to carcinogenesis and explore individual therapy.
Identifiants
pubmed: 38227150
doi: 10.1007/s10555-023-10160-9
pii: 10.1007/s10555-023-10160-9
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chongqing Municipal Public Health Bureau, Chongqing People's Municipal Government
ID : 2018QNXM041
Organisme : Chongqing Basic and Frontier Research Project
ID : cstc2018jcyjAX0645
Organisme : National Natural Science Foundation of China
ID : 81902302
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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