Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Journal
Neural regeneration research
ISSN: 1673-5374
Titre abrégé: Neural Regen Res
Pays: India
ID NLM: 101316351
Informations de publication
Date de publication:
01 Sep 2024
01 Sep 2024
Historique:
received:
30
05
2023
accepted:
07
11
2023
medline:
16
1
2024
pubmed:
16
1
2024
entrez:
16
1
2024
Statut:
ppublish
Résumé
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's disease. A predominant function of the retina is circadian synchronization, carrying information to the brain through the retinohypothalamic tract, which projects to the suprachiasmatic nucleus. Notably, Alzheimer's disease hallmarks, including amyloid-β, are present in the retinas of Alzheimer's disease patients, followed/associated by structural and functional disturbances. However, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in Alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm.
Identifiants
pubmed: 38227523
doi: 10.4103/1673-5374.390962
pii: 01300535-202409000-00026
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1967-1972Informations de copyright
Copyright © 2024 Copyright: © 2024 Neural Regeneration Research.
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