Genomic and transcriptomic profiling of hepatocellular carcinoma reveals a rare molecular subtype.


Journal

Discover. Oncology
ISSN: 2730-6011
Titre abrégé: Discov Oncol
Pays: United States
ID NLM: 101775142

Informations de publication

Date de publication:
16 Jan 2024
Historique:
received: 27 08 2023
accepted: 10 12 2023
medline: 17 1 2024
pubmed: 17 1 2024
entrez: 16 1 2024
Statut: epublish

Résumé

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, occurring predominantly in patients with underlying chronic liver disease and cirrhosis. Here, we describe a case of a 62-year-old man that was admitted to our hospital and diagnosed with HCC where the cancer has already metastasized to the retroperitoneum and peritoneum. In order to better characterize the HCC, both the cancerous liver tissue and the adjacent normal liver tissue of the patient were collected and subjected to a genomic, transcriptomic and proteomic analysis. Our patient carries a highly mutated HCC, which is characterized by both somatic mutation in the following genes ALK, CDK6, TP53, PGR. In addition, we observe several molecular alterations that are associated with potential therapy resistance, for example the expression of the organic-anion-transporting polypeptide (OATP) family members B1 and B3, that mediate the transport of the anticancer drugs, has been found decreased. Overall, our molecular profiling potentially classify the patient with poor prognosis and possibly displaying resistance to pharmacological therapy.

Identifiants

pubmed: 38228856
doi: 10.1007/s12672-023-00850-9
pii: 10.1007/s12672-023-00850-9
doi:

Types de publication

Journal Article

Langues

eng

Pagination

10

Subventions

Organisme : Ministero dell'Università e della Ricerca
ID : MUR-PNRR M4C2I1.3 PE6 project PE00000019 Heal Italia
Organisme : Ministero dell'Università e della Ricerca
ID : MUR-PNRR M4C2I1.3 PE6 project PE00000019 Heal Italia
Organisme : Ministero dell'Università e della Ricerca
ID : MUR-PNRR M4C2I1.3 PE6 project PE00000019 Heal Italia
Organisme : Associazione Italiana per la Ricerca contro il Cancro (AIRC)
ID : IG 2022 ID 27366; 2023-2027
Organisme : Regione Lazio
ID : LazioInnova Progetto Gruppo di Ricerca n 85-2017-14986; n 33 & 55-2021-T0002E0001

Informations de copyright

© 2024. The Author(s).

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Auteurs

Mengting Zhu (M)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.
The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, Soochow University, Suzhou, 215000, China.

Valentina Rovella (V)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.

Manuel Scimeca (M)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.

Alessandro Mauriello (A)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.

Yufang Shi (Y)

The Third Affiliated Hospital of Soochow University, Institutes for Translational Medicine, Soochow University, Suzhou, 215000, China.

Julia Bischof (J)

Indivumed GmbH, Falkenried, 88 Building D, 20251, Hamburg, Germany.

Jonathan Woodsmith (J)

Indivumed GmbH, Falkenried, 88 Building D, 20251, Hamburg, Germany.

Alessandro Anselmo (A)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.

Gerry Melino (G)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy. melino@uniroma2.it.

Giuseppe Tisone (G)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy. tisone@med.uniroma2.it.

Massimiliano Agostini (M)

Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy. m.agostini@med.uniroma2.it.

Classifications MeSH