The Mediator kinase module enhances polymerase activity to regulate transcriptional memory after heat stress in Arabidopsis.
CDK8
Heat Stress
Mediator Kinase Module
RNA Polymerase II
Transcriptional Memory
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
16 Jan 2024
16 Jan 2024
Historique:
received:
26
05
2023
accepted:
14
12
2023
revised:
12
12
2023
medline:
17
1
2024
pubmed:
17
1
2024
entrez:
16
1
2024
Statut:
aheadofprint
Résumé
Plants are often exposed to recurring adverse environmental conditions in the wild. Acclimation to high temperatures entails transcriptional responses, which prime plants to better withstand subsequent stress events. Heat stress (HS)-induced transcriptional memory results in more efficient re-induction of transcription upon recurrence of heat stress. Here, we identified CDK8 and MED12, two subunits of the kinase module of the transcription co-regulator complex, Mediator, as promoters of heat stress memory and associated histone modifications in Arabidopsis. CDK8 is recruited to heat-stress memory genes by HEAT SHOCK TRANSCRIPTION FACTOR A2 (HSFA2). Like HSFA2, CDK8 is largely dispensable for the initial gene induction upon HS, and its function in transcriptional memory is thus independent of primary gene activation. In addition to the promoter and transcriptional start region of target genes, CDK8 also binds their 3'-region, where it may promote elongation, termination, or rapid re-initiation of RNA polymerase II (Pol II) complexes during transcriptional memory bursts. Our work presents a complex role for the Mediator kinase module during transcriptional memory in multicellular eukaryotes, through interactions with transcription factors, chromatin modifications, and promotion of Pol II efficiency.
Identifiants
pubmed: 38228917
doi: 10.1038/s44318-023-00024-x
pii: 10.1038/s44318-023-00024-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : EC | H2020 | PRIORITY 'Excellent science' | H2020 European Research Council (ERC)
ID : 725295
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : CRC973/project A2
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : BA3942/5-1
Informations de copyright
© 2024. The Author(s).
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