Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the consecutive stages of the COVID-19 pandemic in the Netherlands, an update.
COVID-19
Coronavirus
Critical Care
Intensive Care
Mortality
Outcome
Journal
Annals of intensive care
ISSN: 2110-5820
Titre abrégé: Ann Intensive Care
Pays: Germany
ID NLM: 101562873
Informations de publication
Date de publication:
16 Jan 2024
16 Jan 2024
Historique:
received:
27
09
2023
accepted:
27
12
2023
medline:
17
1
2024
pubmed:
17
1
2024
entrez:
16
1
2024
Statut:
epublish
Résumé
Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during the final upsurge of the second wave (February-June 2021) in the Netherlands. We examined whether this decrease persisted during the third wave and the phases with decreasing incidence of COVID-19 thereafter and brought up to date the information on patient characteristics. Data from the National Intensive Care Evaluation (NICE)-registry of all COVID-19 patients admitted to an ICU in the Netherlands were used. Patient characteristics and rates of in-hospital mortality (the primary outcome) during the consecutive periods after the first wave (periods 2-9, May 25, 2020-January 31, 2023) were compared with those during the first wave (period 1, February-May 24, 2020). After adjustment for patient characteristics and ICU occupancy rate, the mortality risk during the initial upsurge of the third wave (period 6, October 5, 2021-January, 31, 2022) was similar to that of the first wave (OR The results show variation in mortality rates among critically ill COVID-19 patients across the calendar time periods that is not explained by differences in case-mix and ICU occupancy rates or by varying proportions of patients with COVID-19 as main reason for ICU admission. The consistent increase in mortality during the initial, rising phase of each separate wave might be caused by the increased virulence of the contemporary virus strain and lacking immunity to the new strain, besides unmeasured patient-, treatment- and healthcare system characteristics.
Sections du résumé
BACKGROUND
BACKGROUND
Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during the final upsurge of the second wave (February-June 2021) in the Netherlands. We examined whether this decrease persisted during the third wave and the phases with decreasing incidence of COVID-19 thereafter and brought up to date the information on patient characteristics.
METHODS
METHODS
Data from the National Intensive Care Evaluation (NICE)-registry of all COVID-19 patients admitted to an ICU in the Netherlands were used. Patient characteristics and rates of in-hospital mortality (the primary outcome) during the consecutive periods after the first wave (periods 2-9, May 25, 2020-January 31, 2023) were compared with those during the first wave (period 1, February-May 24, 2020).
RESULTS
RESULTS
After adjustment for patient characteristics and ICU occupancy rate, the mortality risk during the initial upsurge of the third wave (period 6, October 5, 2021-January, 31, 2022) was similar to that of the first wave (OR
CONCLUSIONS
CONCLUSIONS
The results show variation in mortality rates among critically ill COVID-19 patients across the calendar time periods that is not explained by differences in case-mix and ICU occupancy rates or by varying proportions of patients with COVID-19 as main reason for ICU admission. The consistent increase in mortality during the initial, rising phase of each separate wave might be caused by the increased virulence of the contemporary virus strain and lacking immunity to the new strain, besides unmeasured patient-, treatment- and healthcare system characteristics.
Identifiants
pubmed: 38228972
doi: 10.1186/s13613-023-01238-2
pii: 10.1186/s13613-023-01238-2
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11Subventions
Organisme : The Netherlands Organisation for Health Research and Development (ZonMw)
ID : 10430 01 201 0011: IRIS
Investigateurs
M G W Barnas
(MGW)
D P Boer
(DP)
R J Bosman
(RJ)
G B Brunnekreef
(GB)
M de Graaff
(M)
R M de Jong
(RM)
A R de Meijer
(AR)
W de Ruijter
(W)
R de Waal
(R)
A Dijkhuizen
(A)
T P J Dormans
(TPJ)
A Draisma
(A)
I Drogt
(I)
B J W Eikemans
(BJW)
P W G Elbers
(PWG)
J L Epker
(JL)
M L Erkamp
(ML)
B Festen-Spanjer
(B)
T Frenzel
(T)
L Georgieva
(L)
N C Gritters
(NC)
I Z Hené
(IZ)
S H A Hendriks
(SHA)
M Hoeksema
(M)
J W M Holtkamp
(JWM)
M E Hoogendoorn
(ME)
C J G M Jacobs
(CJGM)
I T A Janssen
(ITA)
H Kieft
(H)
M P Koetsier
(MP)
T J J Koning
(TJJ)
H Kreeftenberg
(H)
N Kusadasi
(N)
J A Lens
(JA)
J G Lutisan
(JG)
D J Mehagnoul-Schipper
(DJ)
D Moolenaar
(D)
F Nooteboom
(F)
R V Pruijsten
(RV)
D Ramnarain
(D)
A C Reidinga
(AC)
E Rengers
(E)
A A Rijkeboer
(AA)
T Rijpstra
(T)
F W Rozendaal
(FW)
R M Schnabel
(RM)
V M Silderhuis
(VM)
J J Spijkstra
(JJ)
P E Spronk
(PE)
L C Urlings-Strop
(LC)
A E van den Berg
(AE)
R van den Berg
(R)
I C C van der Horst
(ICC)
P H J Van der Voort
(PHJ)
E M van Driel
(EM)
L van Gulik
(L)
F M van Iersel
(FM)
M van Lieshout
(M)
J A H van Oers
(JAH)
E R van Slobbe-Bijlsma
(ER)
M van Tellingen
(M)
D P Verbiest
(DP)
D J Versluis
(DJ)
E Verweij
(E)
M de Vrolijk-Mos
(M)
R M J Wesselink
(RMJ)
Informations de copyright
© 2024. The Author(s).
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