Piers-Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
10 Jan 2024
10 Jan 2024
Historique:
received:
08
12
2023
accepted:
08
01
2024
medline:
17
1
2024
pubmed:
17
1
2024
entrez:
17
1
2024
Statut:
epublish
Résumé
A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (-)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers-Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available CBD, in 31% overall yield.
Identifiants
pubmed: 38229717
doi: 10.1039/d3ra08392f
pii: d3ra08392f
pmc: PMC10790624
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2741-2744Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.