Positive Allosteric Modulators of alpha7 Nicotinic Acetylcholine Receptor for the Treatment of Several Central Nervous System Diseases.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
11 Jan 2024
11 Jan 2024
Historique:
received:
16
11
2023
pmc-release:
11
01
2025
medline:
17
1
2024
pubmed:
17
1
2024
entrez:
17
1
2024
Statut:
epublish
Résumé
The invention in this patent application relates to spirocyclopropane-2-carboxamide derivatives represented generally by formula 1. These compounds are positive allosteric modulators of α7 nAChR and may be useful in preventing, treating, or ameliorating central nervous system diseases and disorders such as cognitive impairments in Alzheimer's disease, Parkinson's disease, schizophrenia, and L-DOPA-induced dyskinesia as well as inflammation and cough.
Identifiants
pubmed: 38229741
doi: 10.1021/acsmedchemlett.3c00520
pmc: PMC10788935
doi:
Types de publication
Editorial
Langues
eng
Pagination
6-8Informations de copyright
Published 2023 by American Chemical Society.
Déclaration de conflit d'intérêts
The author declares no competing financial interest.