Development, implementation, and dissemination of operational innovations across the trial innovation network.

CTSA Trial innovation network clinical trial roadblocks clinical trials innovation

Journal

Journal of clinical and translational science
ISSN: 2059-8661
Titre abrégé: J Clin Transl Sci
Pays: England
ID NLM: 101689953

Informations de publication

Date de publication:
2023
Historique:
received: 14 07 2023
revised: 13 10 2023
accepted: 14 10 2023
medline: 17 1 2024
pubmed: 17 1 2024
entrez: 17 1 2024
Statut: epublish

Résumé

Improving the quality and conduct of multi-center clinical trials is essential to the generation of generalizable knowledge about the safety and efficacy of healthcare treatments. Despite significant effort and expense, many clinical trials are unsuccessful. The National Center for Advancing Translational Science launched the Trial Innovation Network to address critical roadblocks in multi-center trials by leveraging existing infrastructure and developing operational innovations. We provide an overview of the roadblocks that led to opportunities for operational innovation, our work to develop, define, and map innovations across the network, and how we implemented and disseminated mature innovations.

Identifiants

DOI: 10.1017/cts.2023.658 PMID: 38229905 PMC: PMC10790103
pubmed: 38229905
doi: 10.1017/cts.2023.658
pii: S2059866123006581
pmc: PMC10790103
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e251

Informations de copyright

© The Author(s) 2023.

Déclaration de conflit d'intérêts

None of the authors have competing interests related to this manuscript.

Auteurs

Marisha E Palm (ME)

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
ORCID: 0000-0002-9760-7196

Terri L Edwards (TL)

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.

Cortney Wieber (C)

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.

Marie T Kay (MT)

University of Utah Health, Salt Lake City, UT, USA.

Eve Marion (E)

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
ORCID: 0000-0002-8559-640X

Leslie Boone (L)

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.

Angeline Nanni (A)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Michelle Jones (M)

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.

Eilene Pham (E)

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.

Meghan Hildreth (M)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Karen Lane (K)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0002-7529-0714

Nichol McBee (N)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Daniel K Benjamin (DK)

Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
Duke University School of Medicine, Durham, NC, USA.

Gordon R Bernard (GR)

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

J Michael Dean (JM)

University of Utah Health, Salt Lake City, UT, USA.

Jamie P Dwyer (JP)

University of Utah Health, Salt Lake City, UT, USA.
Utah Clinical and Translational Sciences Institute, Salt Lake City, UT, USA.

Daniel E Ford (DE)

Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0002-2549-2289

Daniel F Hanley (DF)

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Institute for Clinical and Translational Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ORCID: 0000-0002-9536-4258

Paul A Harris (PA)

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Biomedical Informatics, Biostatistics, and Biomedical Engineering, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0002-1744-2011

Consuelo H Wilkins (CH)

Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Internal Medicine, Meharry Medical College, Nashville, Tennessee, USA.

Harry P Selker (HP)

Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA.
Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA.
ORCID: 0000-0001-5322-7178

Classifications MeSH