Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
19 Jan 2024
Historique:
medline: 17 1 2024
pubmed: 17 1 2024
entrez: 17 1 2024
Statut: ppublish

Résumé

Bone is one of the most common sites of tumor metastases. During the last step of bone metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by osteocytes, the most abundant cells in the bone microenvironment. However, the role of osteocytes in bone metastasis is still unclear. Here, we demonstrated that osteocytes transfer mitochondria to metastatic cancer cells and trigger the cGAS/STING-mediated antitumor response. Blocking the transfer of mitochondria by specifically knocking out mitochondrial Rho GTPase 1 (

Identifiants

DOI: 10.1126/sciadv.adi4298 PMID: 38232158
pubmed: 38232158
doi: 10.1126/sciadv.adi4298
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadi4298

Auteurs

Hao Zhou (H)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
ORCID: 0000-0002-5801-833X

Wenkan Zhang (W)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Hengyuan Li (H)

Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Fan Xu (F)

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
ORCID: 0000-0003-2758-3114

Eloy Yinwang (E)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Yucheng Xue (Y)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Tao Chen (T)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
ORCID: 0000-0002-3958-0423

Shengdong Wang (S)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Zenan Wang (Z)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
ORCID: 0000-0001-8060-0716

Hangxiang Sun (H)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Fangqian Wang (F)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Haochen Mou (H)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Minjun Yao (M)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Xupeng Chai (X)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Jiahao Zhang (J)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Mohamed Diaty Diarra (MD)

Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.

Binghao Li (B)

Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

Changqing Zhang (C)

Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
ORCID: 0000-0002-7408-4126

Junjie Gao (J)

Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
Shanghai Sixth People's Hospital Fujian, No. 16, Luoshan Section, Jinguang Road, Luoshan Street, Jinjiang City, Quanzhou, Fujian, China.
ORCID: 0000-0003-4820-8524

Zhaoming Ye (Z)

Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
ORCID: 0000-0001-5951-5840

Classifications MeSH