Lymph node and tumor-associated PD-L1

DAMPs ICB NF-κB PD-1 TAAs apoptosis damage-associated molecular patterns immune-checkpoint blockers mature regulatory DCs mregDC necroptosis nuclear factor κB programmed cell death-1 single-cell omics tumor-associated antigens

Journal

Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894

Informations de publication

Date de publication:
16 Jan 2024
Historique:
received: 22 08 2022
revised: 23 08 2023
accepted: 18 12 2023
medline: 18 1 2024
pubmed: 18 1 2024
entrez: 17 1 2024
Statut: ppublish

Résumé

Current immunotherapies provide limited benefits against T cell-depleted tumors, calling for therapeutic innovation. Using multi-omics integration of cancer patient data, we predict a type I interferon (IFN) response

Identifiants

DOI: 10.1016/j.xcrm.2023.101377 PMID: 38232703
pubmed: 38232703
pii: S2666-3791(23)00606-7
doi: 10.1016/j.xcrm.2023.101377
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

101377

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.D.G. received honoraria/funding from Boehringer Ingelheim, Miltenyi Biotec, Novigenix, SOTIO, and IsoPlexis.

Auteurs

Jenny Sprooten (J)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Isaure Vanmeerbeek (I)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Angeliki Datsi (A)

Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Jannes Govaerts (J)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Stefan Naulaerts (S)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Raquel S Laureano (RS)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Daniel M Borràs (DM)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Anna Calvet (A)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.

Vanshika Malviya (V)

Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium.

Marc Kuballa (M)

Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Jörg Felsberg (J)

Department of Neurosurgery, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Michael C Sabel (MC)

Department of Neurosurgery, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Marion Rapp (M)

Department of Neurosurgery, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Christiane Knobbe-Thomsen (C)

Department of Neurosurgery, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Peng Liu (P)

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

Liwei Zhao (L)

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

Oliver Kepp (O)

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

Louis Boon (L)

JJP Biologics, Warsaw, Poland.

Sabine Tejpar (S)

Laboratory for Molecular Digestive Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.

Jannie Borst (J)

Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, the Netherlands.

Guido Kroemer (G)

Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.

Susan Schlenner (S)

Department of Microbiology, Immunology and Transplantation, KU Leuven-University of Leuven, Leuven, Belgium.

Steven De Vleeschouwer (S)

Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium; Laboratory of Experimental Neurosurgery and Neuroanatomy, Department of Neurosciences, KU Leuven, Leuven, Belgium; Leuven Brain Institute (LBI), Leuven, Belgium.

Rüdiger V Sorg (RV)

Institute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, Heinrich Heine University Hospital, Düsseldorf, Germany.

Abhishek D Garg (AD)

Laboratory of Cell Stress & Immunity, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium. Electronic address: abhishek.garg@kuleuven.be.

Classifications MeSH