Urine and Dried Blood Spots From Children and Pregnant Women Reveal Phytochemicals, Amino Acids, and Carnitine Metabolites as Cowpea Consumption Biomarkers.
cowpea
dietary exposure biomarkers
dried dlood spots
metabolism
urine
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
17 Jan 2024
17 Jan 2024
Historique:
revised:
23
10
2023
received:
11
04
2023
medline:
18
1
2024
pubmed:
18
1
2024
entrez:
17
1
2024
Statut:
aheadofprint
Résumé
Legumes consumption has been proven to promote health across the lifespan; cowpeas have demonstrated efficacy in combating childhood malnutrition and growth faltering, with an estimated malnutrition prevalence of 35.6% of children in Ghana. This cowpea feeding study aimed to identify a suite of metabolic consumption biomarkers in children and adults. Urine and dried blood spots (DBS) from 24 children (9-21 months) and 21 pregnant women (>18 years) in Northern Ghana are collected before and after dose-escalated consumption of four cowpea varieties for 15 days. Untargeted metabolomics identified significant increases in amino acids, phytochemicals, and lipids. The carnitine metabolism pathway is represented by 137 urine and 43 DBS metabolites, with significant changes to tiglylcarnitine and acetylcarnitine. Additional noteworthy candidate biomarkers are mansouramycin C, N-acetylalliin, proline betaine, N2, N5-diacetylornithine, S-methylcysteine, S-methylcysteine sulfoxide, and cis-urocanate. S-methylcysteine and S-methylcysteine sulfoxide are targeted and quantified in urine. This feeding study for cowpea biomarkers supports the utility of a suite of key metabolites classified as amino acids, lipids, and phytochemicals for dietary legume and cowpea-specific food exposures of global health importance.
Identifiants
pubmed: 38233141
doi: 10.1002/mnfr.202300222
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300222Subventions
Organisme : United States Agency for International Development
ID : 7200AA18LE00003
Informations de copyright
© 2024 Wiley-VCH GmbH.
Références
M. Carvalho, I. Castro, J. Moutinho-Pereira, C. Correia, M. Egea-Cortines, M. Matos, E. Rosa, V. Carnide, T. Lino-Neto, J. Plant Physiol. 2019, 241, 153001
R. N. Tharanathan, S. Mahadevamma, Trends Food Sci. Technol. 2003, 14, 507
A. S. Langyintuo, J. Lowenberg-DeBoer, M. Faye, D. Lambert, G. Ibro, B. Moussa, A. Kergna, S. Kushwaha, S. Musa, G. Ntoukam, Field Crops Res. 2003, 82, 215
M. Muñoz-Amatriaín, H. Mirebrahim, P. Xu, S. I. Wanamaker, M. Luo, H. Alhakami, M. Alpert, I. Atokple, B. J. Batieno, O. Boukar, S. Bozdag, N. Cisse, I. Drabo, J. D. Ehlers, A. Farmer, C. Fatokun, Y. Q. Gu, Y.-N. Guo, B.-L. Huynh, S. A. Jackson, F. Kusi, C. T. Lawley, M. R. Lucas, Y. Ma, M. P. Timko, J. Wu, F. You, N. A. Barkley, P. A. Roberts, S. Lonardi, et al., Plant J. 2017, 89, 1042
J. E. Ewusie, J. Beyene, C. Ahiadeke, J. S. Hamid, Matern Child Health J.s 2017, 21, 797
N. M. Mehta, M. R. Corkins, B. Lyman, A. Malone, P. S. Goday, L. (Nieman) Carney, J. L. Monczka, S. W. Plogsted, W. F. Schwenk, the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Board of Directors, JPEN J. Parenter Enteral Nutr. 2013, 37, 460
World Health Organization, 2021
United Nations International Children's Emergency Fund (UNICEF), 2017
Z. A. Bhutta, J. A. Berkley, R. H. J. Bandsma, M. Kerac, I. Trehan, A. Briend, Nat. Rev. Dis. Primers 2017, 3, 17067
USAID, 2018, 7
F. Zhu, B. Du, B. Xu, Crit. Rev. Food Sci. Nutr. 2018, 58, 1260
W. Sato, C. Furuta, K. Matsunaga, P. Bahwere, S. Collins, K. Sadler, P. Akomo, C. Banda, E. Maganga, S. Kathumba, H. Murakami, PLoS One 2018, 13, e0201686
K. B. Stephenson, S. E. Agapova, O. Divala, Y. Kaimila, K. M. Maleta, C. Thakwalakwa, M. I. Ordiz, I. Trehan, M. J. Manary, Am. J. Clin. Nutr. 2017, 106, 1500
V. Di Giovanni, C. Bourdon, D. X. Wang, S. Seshadri, E. Senga, C. J. Versloot, W. Voskuijl, R. D. Semba, I. Trehan, R. Moaddel, M. I. Ordiz, L. Zhang, J. Parkinson, M. J. Manary, R. H. Bandsma, J. Nutr. 2016, 146, 2436
T. Perera, M. R. Young, Z. Zhang, G. Murphy, N. H. Colburn, E. Lanza, T. J. Hartman, A. J. Cross, G. Bobe, Mol. Nutr. Food Res. 2015, 59, 795
F. Madrid-Gambin, C. Brunius, M. Garcia-Aloy, S. Estruel-Amades, R. Landberg, C. Andres-Lacueva, J. Agric. Food Chem. 2018, 66, 6997
K. J. Li, E. C. Borresen, N. Jenkins-Puccetti, G. Luckasen, E. P. Ryan, Front. Nutr. 2018, 4, 71
I. Zarei, B. A. Baxter, R. C. Oppel, E. C. Borresen, R. J. Brown, E. P. Ryan, Cancer Prev. Res. 2021, 14, 497
Yukiko Morimoto, Fanchon Beckford, Adrian A Franke, Gertraud Maskarinec, Asia Pac. J. Clin. Nutr. 2014, 23, https://doi.org/10.6133/apjcn.2014.23.2.19
B. A. Baxter, K. J. Li, I. Zarei, L. Yao, S. Rao, E. P. Ryan, J. Agric. Food Chem. 2022, https://doi.org/10.1021/acs.jafc.2c02378.
Y. Zhu, P. Wang, W. Sha, S. Sang, Sci. Rep. 2016, 6, 36278
B. A. Pfluger, H. V. Smith, A. M. Weber, H. Ibrahim, L. Doumbia, A. Bore, A. Cissoko, S. Douyon, K. Kone, L. Sangare, A. Maiga, O. A. Koita, K. Goodman, A. M. Evans, E. P. Ryan, Nutrients 2022, 14, 609
N. H. Tobin, A. Murphy, F. Li, S. S. Brummel, T. E. Taha, F. Saidi, M. Owor, A. Violari, D. Moodley, B. Chi, K. D. Goodman, B. Koos, G. M. Aldrovandi, Metabolomics 2021, 17, 62
E. B. Hill, B. A. Baxter, B. Pfluger, C. K. Slaughter, M. Beale, H. V. Smith, S. S. Stromberg, M. Tipton, H. Ibrahim, S. Rao, H. Leach, E. P. Ryan, Front. Gastroenterol. 2023, 2, 1087056
B. Sayre-Chavez, B. Baxter, C. D. Broeckling, M. Muñoz-Amatriaín, M. Manary, E. P. Ryan, Food Chem.: Mol. Sci. 2022, 4, 100087
A. T. Tsamo, H. Mohammed, M. Mohammed, P. Papoh Ndibewu, F. Dapare Dakora, Nat. Prod. Res. 2020, 34, 1158
Y. Picó, R. Alvarez-Ruiz, L. Wijaya, A. Alfarhan, M. Alyemeni, D. Barceló, Anal. Bioanal. Chem. 2018, 410, 1163
H. Pontzer, Y. Yamada, H. Sagayama, P. N. Ainslie, L. F. Andersen, L. J. Anderson, L. Arab, I. Baddou, K. Bedu-Addo, E. E. Blaak, S. Blanc, A. G. Bonomi, C. V. C. Bouten, P. Bovet, M. S. Buchowski, N. F. Butte, S. G. Camps, G. L. Close, J. A. Cooper, R. Cooper, S. K. Das, L. R. Dugas, U. Ekelund, S. Entringer, T. Forrester, B. W. Fudge, A. H. Goris, M. Gurven, C. Hambly, A. El Hamdouchi, et al., IAEA DLW Database Consortium§, Science 2021, 373, 808
J. Gu, L. Jing, X. Ma, Z. Zhang, Q. Guo, Y. Li, J. Nutr. Biochem. 2015, 26, 1509
C. Li, F. Imamura, R. Wedekind, I. D. Stewart, M. Pietzner, E. Wheeler, N. G. Forouhi, C. Langenberg, A. Scalbert, N. J. Wareham, Am. J. Clin. Nutr. 2022, nqac094
P. Kumari, R. Kumar, D. Singh, R. Kumar, Mol. Biol. Rep. 2023, 50, 6381
Y. Wang, R. A. Hodge, V. L. Stevens, T. J. Hartman, M. L. McCullough, Metabolites 2020, 10, 382
S. Kuang, G. Liu, R. Cao, L. Zhang, Q. Yu, C. Sun, Oncotarget 2017, 8, 104057
R. Lang, T. Lang, M. Bader, A. Beusch, V. Schlagbauer, T. Hofmann, J. Agric. Food Chem. 2017, 65, 1613
W. Wang, B. Sun, P. Hu, M. Zhou, S. Sun, P. Du, Y. Ru, A. Suvorov, Y. Li, Y. Liu, S. Wang, Metabolites 2019, 9, 176
C. W. Kuzawa, H. T. Chugani, L. I. Grossman, L. Lipovich, O. Muzik, P. R. Hof, D. E. Wildman, C. C. Sherwood, W. R. Leonard, N. Lange, Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 13010
K. Hanhineva, M. A. Lankinen, A. Pedret, U. Schwab, M. Kolehmainen, J. Paananen, V. de Mello, R. Sola, M. Lehtonen, K. Poutanen, M. Uusitupa, H. Mykkänen, J. Nutr. 2015, 145, 7
L. F. Enthoven, Y. Shi, E. E. Fay, S. Moreni, J. Mao, E. M. Honeyman, C. K. Smith, D. Whittington, S. E. Brockerhoff, N. Isoherranen, R. A. Totah, M. F. Hebert, Metabolites 2023, 13, 242
B. Kochlik, C. Gerbracht, T. Grune, D. Weber, Mol. Nutr. Food Res. 2018, 62, 1701062
C. M. Rebholz, A. H. Lichtenstein, Z. Zheng, L. J. Appel, J. Coresh, Am. J. Clin. Nutr. 2018, 108, 243