Injectable, Antioxidative, and Tissue-Adhesive Nanocomposite Hydrogel as a Potential Treatment for Inner Retina Injuries.
antioxidant hydrogel
gelatin
injectable hydrogel
nanoparticles
optic nerve
photo-crosslinkable
retinal tissue
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
05
01
2024
received:
11
11
2023
pubmed:
18
1
2024
medline:
18
1
2024
entrez:
17
1
2024
Statut:
ppublish
Résumé
Reactive oxygen species (ROS) have been recognized as prevalent contributors to the development of inner retinal injuries including optic neuropathies such as glaucoma, non-arteritic anterior ischemic optic neuropathy, traumatic optic neuropathy, and Leber hereditary optic neuropathy, among others. This underscores the pivotal significance of oxidative stress in the damage inflicted upon retinal tissue. To combat ROS-related challenges, this study focuses on creating an injectable and tissue-adhesive hydrogel with tailored antioxidant properties for retinal applications. GelCA, a gelatin-modified hydrogel with photo-crosslinkable and injectable properties, is developed. To enhance its antioxidant capabilities, curcumin-loaded polydopamine nanoparticles (Cur@PDA NPs) are incorporated into the GelCA matrix, resulting in a multifunctional nanocomposite hydrogel referred to as Cur@PDA@GelCA. This hydrogel exhibits excellent biocompatibility in both in vitro and in vivo assessments, along with enhanced tissue adhesion facilitated by NPs in an in vivo model. Importantly, Cur@PDA@GelCA demonstrates the potential to mitigate oxidative stress when administered via intravitreal injection in retinal injury models such as the optic nerve crush model. These findings underscore its promise in advancing retinal tissue engineering and providing an innovative strategy for acute neuroprotection in the context of inner retinal injuries.
Identifiants
pubmed: 38233151
doi: 10.1002/advs.202308635
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2308635Subventions
Organisme : National Taiwan University
Organisme : National Taiwan University Hospital
Organisme : Ministry of Science and Technology, Taiwan
ID : 112-2628-E-002 -017 -MY3
Organisme : Ministry of Science and Technology, Taiwan
ID : 111-2221-E-002: -: 117
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.
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