Flexible, scalable, high channel count stereo-electrode for recording in the human brain.

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
17 Jan 2024
Historique:
received: 30 12 2022
accepted: 14 11 2023
medline: 18 1 2024
pubmed: 18 1 2024
entrez: 17 1 2024
Statut: epublish

Résumé

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.

Identifiants

DOI: 10.1038/s41467-023-43727-9 PMID: 38233418
pubmed: 38233418
doi: 10.1038/s41467-023-43727-9
pii: 10.1038/s41467-023-43727-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

218

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : UG3NS123723-01
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
ID : R01NS123655-01
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB)
ID : DP2-EB029757
Organisme : NSF | ENG/OAD | Division of Electrical, Communications and Cyber Systems (ECCS)
ID : 1351980
Organisme : NSF | ENG/OAD | Division of Civil, Mechanical and Manufacturing Innovation (CMMI)
ID : 1728497
Organisme : U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)
ID : R01DA050159-04

Informations de copyright

© 2024. The Author(s).

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Auteurs

Keundong Lee (K)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Angelique C Paulk (AC)

Department of Neurology, Harvard Medical School, Boston, MA, 02114, USA.
Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0002-4413-3417

Yun Goo Ro (YG)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
ORCID: 0000-0002-7023-086X

Daniel R Cleary (DR)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Department of Neurological Surgery, University of California San Diego, La Jolla, CA, 92093, USA.

Karen J Tonsfeldt (KJ)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, CA, 92093, USA.
ORCID: 0000-0001-8044-8857

Yoav Kfir (Y)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.

John S Pezaris (JS)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.

Youngbin Tchoe (Y)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Jihwan Lee (J)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Andrew M Bourhis (AM)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Ritwik Vatsyayan (R)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Joel R Martin (JR)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Samantha M Russman (SM)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.
ORCID: 0000-0003-2742-5300

Jimmy C Yang (JC)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.

Amy Baohan (A)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.

R Mark Richardson (RM)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0003-2620-7387

Ziv M Williams (ZM)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0002-0017-0048

Shelley I Fried (SI)

Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.
Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0001-6456-8656

U Hoi Sang (U)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

Ahmed M Raslan (AM)

Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, 97239, USA.

Sharona Ben-Haim (S)

Department of Neurological Surgery, University of California San Diego, La Jolla, CA, 92093, USA.

Eric Halgren (E)

Department of Radiology, University of California San Diego, La Jolla, CA, 92093, USA.

Sydney S Cash (SS)

Department of Neurology, Harvard Medical School, Boston, MA, 02114, USA.
Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.
ORCID: 0000-0002-4557-6391

Shadi A Dayeh (SA)

Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA. sdayeh@ucsd.edu.
ORCID: 0000-0002-1756-1774

Classifications MeSH