Microglia contribute to mammary tumor-induced neuroinflammation in a female mouse model.
amygdala
astrocytes
brain
cancer
cytokine
hippocampus
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
31 Jan 2024
31 Jan 2024
Historique:
revised:
13
11
2023
received:
03
08
2023
accepted:
27
12
2023
medline:
18
1
2024
pubmed:
18
1
2024
entrez:
18
1
2024
Statut:
ppublish
Résumé
Following diagnosis but before treatment, up to 30% of breast cancer patients report behavioral side effects (e.g., anxiety, depression, memory impairment). Our rodent mammary tumor model recapitulates aspects of these behavioral sequelae, as well as elevated circulating and brain inflammatory mediators. Neuroinflammation is a proposed mechanism underlying the etiology of mood disorders and cognitive deficits, and therefore may be contributing to tumor-associated behavioral side effects. The cellular mechanisms by which tumor-induced neuroinflammation occurs remain unknown, making targeted treatment approaches inaccessible. Here, we tested the hypotheses that microglia are the primary cells driving tumor-induced neuroinflammation and behavioral side effects. Young adult female BALB/c mice were induced with a 67NR mammary tumor; tumor-free controls underwent a sham surgery. Mammary tumors increased IBA1
Identifiants
pubmed: 38236370
doi: 10.1096/fj.202301580RR
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e23419Subventions
Organisme : HHS | NIH | National Cancer Institute (NCI)
ID : R01CA21690
Informations de copyright
© 2024 Federation of American Societies for Experimental Biology.
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