Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
18 Jan 2024
Historique:
medline: 18 1 2024
pubmed: 18 1 2024
entrez: 18 1 2024
Statut: aheadofprint

Résumé

Retinoid X receptors (RXRs, NR2B1-3) hold therapeutic potential in oncology, neurodegeneration, and metabolic diseases, but traditional RXR agonists mimicking the natural ligand 9-

Identifiants

DOI: 10.1021/acs.jmedchem.3c02095 PMID: 38237049
pubmed: 38237049
doi: 10.1021/acs.jmedchem.3c02095
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Max Lewandowski (M)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.
ORCID: 0009-0007-0497-6464

Melania Carmina (M)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.
Department of Pharmaceutical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy.

Loris Knümann (L)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.

Minh Sai (M)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.
ORCID: 0009-0004-6053-9566

Sabine Willems (S)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.
ORCID: 0000-0002-9755-3394

Till Kasch (T)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.

Julius Pollinger (J)

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.

Stefan Knapp (S)

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
ORCID: 0000-0001-5995-6494

Julian A Marschner (JA)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.

Apirat Chaikuad (A)

Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.
ORCID: 0000-0003-1120-2209

Daniel Merk (D)

Department of Pharmacy, Ludwig-Maximilians-Universität (LMU) München, 81377 Munich, Germany.
ORCID: 0000-0002-5359-8128

Classifications MeSH