Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice.

hepatocyte insulin resistance lipid metabolism liver obesity triglyceride

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
16 Jan 2024
Historique:
received: 24 10 2023
revised: 24 12 2023
accepted: 27 12 2023
medline: 19 1 2024
pubmed: 19 1 2024
entrez: 18 1 2024
Statut: aheadofprint

Résumé

Endoplasmic reticulum (ER) stress is associated with insulin resistance and the development of nonalcoholic fatty liver disease (NAFLD). Deficiency of the ER stress response TDAG51 gene (TDAG51

Identifiants

DOI: 10.1016/j.jbc.2024.105655 PMID: 38237682
pubmed: 38237682
pii: S0021-9258(24)00031-0
doi: 10.1016/j.jbc.2024.105655
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105655

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

CONFLICT OF INTEREST The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Tamana R Yousof (TR)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Celeste C Bouchard (CC)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Mihnea Alb (M)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Edward G Lynn (EG)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Sárka Lhoták (S)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Hua Jiang (H)

Department of Pediatrics, University of Colorado Health Sciences Center, School of Medicine, Aurora, Colorado, USA.

Melissa MacDonald (M)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Hui Li (H)

Department of Pharmacology and Toxicology, University of Arizona.

Jae H Byun (JH)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Yumna Makda (Y)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada.

Maria Athanasopoulos (M)

Department of Biology, McMaster University.

Kenneth N Maclean (KN)

Department of Pediatrics, University of Colorado Health Sciences Center, School of Medicine, Aurora, Colorado, USA.

Nathan Cherrington (N)

Department of Pharmacology and Toxicology, University of Arizona.

Asghar Naqvi (A)

Department of Pathology and Molecular Medicine, St. Joseph's Healthcare Hamilton, and McMaster University.

Suleiman Igdoura (S)

Department of Biology, McMaster University; Department of Pathology and Molecular Medicine, McMaster University.

Joan C Krepinsky (JC)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; Centre for Metabolism, Obesity and Diabetes Research, McMaster University.

Gregory R Steinberg (GR)

Department of Medicine, Division of Endocrinology, McMaster University; Centre for Metabolism, Obesity and Diabetes Research, McMaster University.

Richard C Austin (RC)

Department of Medicine, Division of Nephrology, McMaster University, The Research Institute of St. Joe's Hamilton and the Hamilton Centre for Kidney Research, Hamilton, Ontario, Canada; Centre for Metabolism, Obesity and Diabetes Research, McMaster University. Electronic address: austinr@taari.ca.

Classifications MeSH