Opsin-Free Activation of Bmp Receptors by a Femtosecond Laser.
BMP receptors
conformational change
opsin-free activation
signaling pathways
two-photon excitation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
18 Jan 2024
18 Jan 2024
Historique:
revised:
13
12
2023
received:
25
10
2023
medline:
19
1
2024
pubmed:
19
1
2024
entrez:
19
1
2024
Statut:
aheadofprint
Résumé
Bone morphogenetic protein (BMP) signaling plays a vital role in differentiation, organogenesis, and various cell processes. As a member of TGF-β superfamily, the BMP initiation usually accompanies crosstalk with other signaling pathways and simultaneously activates some of them. It is quite challenging to solely initiate an individual pathway. In this study, an opsin-free optical method to specifically activate BMP receptors (BMPR) and subsequent pSmad1/5/8 cascades by a single-time scan of a tightly-focused femtosecond laser in the near infrared range is reported. Via transient two-photon excitation to intrinsic local flavins near the cell membrane, the photoactivation drives conformational changes of preformed BMPR complexes to enable their bonding and phosphorylation of the GS domain in BMPR-I by BMPR-II. The pSmad1/5/8 signaling is initiated by this method, while p38 and pSmad2 are rarely perturbed. Based on a microscopic system, primary adipose-derived stem cells in an area of 420 × 420 µm
Identifiants
pubmed: 38239021
doi: 10.1002/advs.202308072
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2308072Subventions
Organisme : National Natural Science Foundation of China
ID : 92054105
Organisme : National Natural Science Foundation of China
ID : 62022056
Organisme : National Natural Science Foundation of China
ID : 61975118
Organisme : Shanghai Jiao Tong University
ID : YG2022QN063
Informations de copyright
© 2024 The Authors. Advanced Science published by Wiley-VCH GmbH.
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