Infant lung function and early skin barrier impairment in the development of asthma at age 3 years.
PreventADALL
asthma
infants
lung function
skin barrier function
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
18 Jan 2024
18 Jan 2024
Historique:
revised:
08
12
2023
received:
05
06
2023
accepted:
17
12
2023
medline:
19
1
2024
pubmed:
19
1
2024
entrez:
19
1
2024
Statut:
aheadofprint
Résumé
Largely unexplored, we investigated if lower lung function, impaired skin barrier function by transepidermal water loss (TEWL), eczema, and filaggrin (FLG) mutations in infancy were associated with asthma in early childhood. From the factorially designed randomized controlled intervention study PreventADALL, we evaluated 1337/2394 children from all randomization groups with information on asthma at age 3 years, and at age 3 months either lung function, TEWL, eczema, and/or FLG mutations. Lower lung function was defined as the time to peak tidal expiratory flow to expiratory time (t Lower lung function and skin barrier impairment were associated with asthma in general; aOR (95% CI) 5.4 (2.1, 13.7) and 1.6 (1.1, 2.5), while eczema and FLG mutations were associated with asthma in children with atopic dermatitis or allergic sensitization only. Stratifying for sex, the risk of asthma was only increased in boys with lower lung function; aOR (95% CI) 7.7 (2.5, 23.6), and in girls with FLG mutations; aOR (95% CI) 3.5 (1.5, 8.2). Lower lung function and impaired skin barrier function in infancy may increase the risk of asthma at age 3 years.
Sections du résumé
BACKGROUND
BACKGROUND
Largely unexplored, we investigated if lower lung function, impaired skin barrier function by transepidermal water loss (TEWL), eczema, and filaggrin (FLG) mutations in infancy were associated with asthma in early childhood.
METHODS
METHODS
From the factorially designed randomized controlled intervention study PreventADALL, we evaluated 1337/2394 children from all randomization groups with information on asthma at age 3 years, and at age 3 months either lung function, TEWL, eczema, and/or FLG mutations. Lower lung function was defined as the time to peak tidal expiratory flow to expiratory time (t
RESULTS
RESULTS
Lower lung function and skin barrier impairment were associated with asthma in general; aOR (95% CI) 5.4 (2.1, 13.7) and 1.6 (1.1, 2.5), while eczema and FLG mutations were associated with asthma in children with atopic dermatitis or allergic sensitization only. Stratifying for sex, the risk of asthma was only increased in boys with lower lung function; aOR (95% CI) 7.7 (2.5, 23.6), and in girls with FLG mutations; aOR (95% CI) 3.5 (1.5, 8.2).
CONCLUSION
CONCLUSIONS
Lower lung function and impaired skin barrier function in infancy may increase the risk of asthma at age 3 years.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Norwegian Research Council
Organisme : South-Eastern Norway Regional Health Authority
Organisme : The University of Oslo
Organisme : Oslo University Hospital
Organisme : The Foundation for Healthcare and Allergy Research in Sweden -Vårdalstiftelsen
Organisme : Health and Rehabilitation Norway
Organisme : Fürst Medical Laboratory, Oslo, Norway
Organisme : Thermo Fisher Scientific, Uppsala, Sweden
Organisme : Arne Ingel's legat
Organisme : Norwegian Society of Dermatology and Venerology
Organisme : Forskningsrådet om Hälsa, Arbetsliv och Välfärd
Organisme : Region Stockholm
Organisme : The Sven Jerring Foundation
Organisme : Swedish Order of Freemasons Foundation Barnhuset
Organisme : The Swedish Research Council - the Initiative for Clinical Therapy Research
Organisme : SFO-V Karolinska Institutet
Organisme : The Swedish Heart-Lung Foundation
Organisme : Sykehuset Østfold
Organisme : The Kloster foundation
Organisme : The Norwegian Association of Asthma and Allergy
Organisme : Barnestiftelsen at Oslo University Hospital
Organisme : The Samaritan Foundation for Pediatric Research
Organisme : The Frithjof Nansen Institute
Organisme : Roche
Organisme : The Magnus Bergwall foundation
Organisme : The Hesselman Foundation
Organisme : The Swedish Society of Medicine
Organisme : The Konsul Th C Bergh's Foundation
Organisme : KI grants
Organisme : The King Gustaf V 80th Birthday Foundation
Organisme : The Pediatric Research Foundation at Astrid Lindgren Children's Hospital
Organisme : The Cancer- and Allergy Foundation
Organisme : The Swedish Asthma and Allergy Association's Research Foundation
Informations de copyright
© 2024 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
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