Motor dysfunction as a primary symptom predicts poor outcome: multicenter study of glioma symptoms.
brain neoplasm
cognitive disorder
epilepsy
glioma
headache
motor dysfunction
prognosis
symptoms
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
10
2023
accepted:
27
11
2023
medline:
19
1
2024
pubmed:
19
1
2024
entrez:
19
1
2024
Statut:
epublish
Résumé
The objectives of this study were to investigate the prognostic value of primary symptoms and leading symptoms in adult patients with diffuse infiltrating glioma and to provide a clinical perspective for evaluating survival. This study included a retrospective cohort from two tertiary university hospitals ( The most common primary symptoms were epileptic seizure (30.8% retrospective, 28.2% prospective), cognitive disorder (13.2% retrospective, 16.0% prospective), headache (8.6% retrospective, 12.8% prospective), and motor paresis (7.0% retrospective, 7.1% prospective). Symptoms that predicted better survival were epileptic seizure and visual or other sense-affecting symptom in the retrospective cohort and epileptic seizure and headache in the prospective cohort. Predictors of poor survival were cognitive disorder, motor dysfunction, sensory symptom, tumor hemorrhage, speech disorder and dizziness in the retrospective cohort and cognitive disorder, motor dysfunction, sensory symptom, and dizziness in the prospective cohort. Motor dysfunction served as an independent predictor of survival in a multivariate model (OR = 1.636). Primary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas.
Sections du résumé
Background and objectives
UNASSIGNED
The objectives of this study were to investigate the prognostic value of primary symptoms and leading symptoms in adult patients with diffuse infiltrating glioma and to provide a clinical perspective for evaluating survival.
Methods
UNASSIGNED
This study included a retrospective cohort from two tertiary university hospitals (
Results
UNASSIGNED
The most common primary symptoms were epileptic seizure (30.8% retrospective, 28.2% prospective), cognitive disorder (13.2% retrospective, 16.0% prospective), headache (8.6% retrospective, 12.8% prospective), and motor paresis (7.0% retrospective, 7.1% prospective). Symptoms that predicted better survival were epileptic seizure and visual or other sense-affecting symptom in the retrospective cohort and epileptic seizure and headache in the prospective cohort. Predictors of poor survival were cognitive disorder, motor dysfunction, sensory symptom, tumor hemorrhage, speech disorder and dizziness in the retrospective cohort and cognitive disorder, motor dysfunction, sensory symptom, and dizziness in the prospective cohort. Motor dysfunction served as an independent predictor of survival in a multivariate model (OR = 1.636).
Conclusion
UNASSIGNED
Primary and leading symptoms in diffuse gliomas are associated with prognoses in retrospective and prospective settings. Motor paresis was an independent prognostic factor for poor survival in multivariate analysis for grade 2-4 diffuse gliomas, especially in glioblastomas.
Identifiants
pubmed: 38239655
doi: 10.3389/fonc.2023.1305725
pmc: PMC10794640
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1305725Informations de copyright
Copyright © 2024 Kivioja, Posti, Sipilä, Rauhala, Frantzén, Gardberg, Rahi, Rautajoki, Nykter, Vuorinen, Nordfors, Haapasalo and Haapasalo.
Déclaration de conflit d'intérêts
Authors HH and JH were employed by the company Fimlab Laboratories Ltd, which is a public limited company. Individual funding outside of this submitted work: Academy of Finland #17379 to JP; Government’s Special Financial Transfer tied to academic research in Health Sciences, Finland #11129 to JP; the Maire Taponen Foundation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.