Rheological, cardiorespiratory and cerebrovascular effects of pentoxifylline following acclimatization to 3800 meters.

blood viscosity cerebral blood flow chemoreflex high altitude hypoxic pulmonary vasoconstriction

Journal

American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228

Informations de publication

Date de publication:
19 Jan 2024
Historique:
medline: 19 1 2024
pubmed: 19 1 2024
entrez: 19 1 2024
Statut: aheadofprint

Résumé

Pentoxifylline is a non-selective phosphodiesterase inhibitor used for the treatment of peripheral artery disease. Pentoxifylline acts through cyclic adenosine monophosphate, thereby enhancing red blood cell deformability, causing vasodilation and decreasing inflammation, and potentially stimulating ventilation. We conducted a double-blind, placebo-controlled,

Identifiants

DOI: 10.1152/ajpheart.00783.2023 PMID: 38241007
pubmed: 38241007
doi: 10.1152/ajpheart.00783.2023
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (NSERC)
Organisme : Principal's Research Chair

Auteurs

Andrew R Steele (AR)

Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.

Connor A Howe (CA)

University of British Columbia, Vancouver, Canada.

Travis D Gibbons (TD)

School of Physical Education, Sport and Exercise Sciences, University of Otago; Centre for Heart, Lung and Vascular Health, University of British Columbia-Okanagan, Kelowna, BC, Canada.

Katharine Foster (K)

Loma Linda University, United States.

Alexandra M Williams (AM)

Centre for Heart, Lung and Vascular Health, University of British Columbia Okanagan, Kelowna, BC, Canada; Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Vancouver, British Columbia, Canada.

Hannah G Caldwell (HG)

University of British Columbia Okanagan.

L Madden Brewster (LM)

Department of Health and Social Development, University of British Columbia - Okanagan, British Columbia, Canada.

Jennifer Duffy (J)

University of British Columbia, Canada.

Justin A Monteleone (JA)

University of British Columbia, Canada.

Prajan Subedi (P)

Loma Linda University.

James D Anholm (JD)

Pulmonary/Critical Care Medicine, Loma Linda University, Loma Linda, CA, Loma Linda, CA, United States.

Mike Stembridge (M)

Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, Wales, Wales.

Philip N Ainslie (PN)

Centre for Heart, Lung and Vascular Health, University of British Columbia, Kelowna, BC, Canada.

Joshua C Tremblay (JC)

Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom.

Classifications MeSH