Interaction of PINK1 with nucleotides and kinetin.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
19 Jan 2024
Historique:
medline: 19 1 2024
pubmed: 19 1 2024
entrez: 19 1 2024
Statut: ppublish

Résumé

The ubiquitin kinase PINK1 accumulates on damaged mitochondria to trigger mitophagy, and PINK1 loss-of-function mutations cause early onset Parkinson's disease. Nucleotide analogs such as kinetin triphosphate (KTP) were reported to enhance PINK1 activity and may represent a therapeutic strategy for the treatment of Parkinson's disease. Here, we investigate the interaction of PINK1 with nucleotides, including KTP. We establish a cryo-EM platform exploiting the dodecamer assembly of

Identifiants

DOI: 10.1126/sciadv.adj7408 PMID: 38241364
pubmed: 38241364
doi: 10.1126/sciadv.adj7408
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj7408

Auteurs

Zhong Yan Gan (ZY)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0001-5755-7780

Sylvie Callegari (S)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0002-4402-945X

Thanh N Nguyen (TN)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
ORCID: 0000-0001-9698-0020

Nicholas S Kirk (NS)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0001-5028-6308

Andrew Leis (A)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0003-4905-9401

Michael Lazarou (M)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia.
ORCID: 0000-0003-2150-5545

Grant Dewson (G)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0003-4251-8898

David Komander (D)

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.
ORCID: 0000-0002-8092-4320

Classifications MeSH