Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization.

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
19 Jan 2024
Historique:
medline: 19 1 2024
pubmed: 19 1 2024
entrez: 19 1 2024
Statut: aheadofprint

Résumé

New potent, selective monoacylglycerol lipase (MAGL) inhibitors based on the azetidin-2-one scaffold ((±)-

Identifiants

DOI: 10.1021/acs.jmedchem.3c01278 PMID: 38241614
pubmed: 38241614
doi: 10.1021/acs.jmedchem.3c01278
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Stefania Butini (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-8471-0880

Uwe Grether (U)

Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
ORCID: 0000-0002-3164-9270

Kwang-Mook Jung (KM)

Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697, United States.
ORCID: 0000-0003-4096-6953

Alessia Ligresti (A)

Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
ORCID: 0000-0003-1787-3900

Marco Allarà (M)

Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.

Annemarieke G J Postmus (AGJ)

Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University and Oncode Institute, 2300 CC, Leiden, Netherlands.

Samuele Maramai (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0001-7499-6961

Simone Brogi (S)

Department of Pharmacy, University of Pisa, via Bonanno, 56126 Pisa, Italy.
ORCID: 0000-0001-9375-6242

Alessandro Papa (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

Gabriele Carullo (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-1619-3295

David Sykes (D)

Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Edgbaston, B15 2TT Birmingham, Midlands, United Kingdom.

Dmitry Veprintsev (D)

Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.
ORCID: 0000-0002-3583-5409

Stefano Federico (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-7478-6128

Alessandro Grillo (A)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

Bruno Di Guglielmo (B)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

Anna Ramunno (A)

Department of Pharmacy/DIFARMA, University of Salerno, via Giovanni Paolo II 132, Salerno 84084, Fisciano, Italy.
ORCID: 0000-0003-1089-2439

Anna Floor Stevens (AF)

Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University and Oncode Institute, 2300 CC, Leiden, Netherlands.

Dominik Heer (D)

Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.
ORCID: 0009-0003-2089-4339

Stefania Lamponi (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.

Sandra Gemma (S)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
ORCID: 0000-0002-8313-2417

Jörg Benz (J)

Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland.

Vincenzo Di Marzo (V)

Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Centre Nutrition, Santé et Société (NUTRISS), Institut sur La Nutrition Et Les Aliments Fonctionnels (INAF), École de Nutrition, Université Laval, 2440 Boulevard Hochelaga, Québec G1V 0A6, Canada.
Canada Excellence Research Chair in the Microbiome-Endocannabinoidome Axis in Metabolic Health, PO Box 2325, Quebec G1V 0A6, Canada.
Centre de Recherche de l'Institut de Cardiologie et de Pneumologie de Québec, Faculté de Médecine, Département de Médecine, Université Laval, PO Box 2725, Québec G1V 4G5, Canada.
Unité Mixte Internationale en Recherche Chimique et Biomoléculaire sur le Microbiome et Son Impact Sur la Santé Métabolique et la Nutrition (UMI-MicroMeNu), Université Laval, PO Box 2325, Quebec G1V 0A6, Canada.

Mario van der Stelt (M)

Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University and Oncode Institute, 2300 CC, Leiden, Netherlands.

Daniele Piomelli (D)

Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697, United States.
ORCID: 0000-0002-2983-774X

Giuseppe Campiani (G)

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy.
Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-7346, Iran.

Classifications MeSH