Microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
19 Jan 2024
19 Jan 2024
Historique:
received:
03
12
2022
accepted:
12
01
2024
medline:
20
1
2024
pubmed:
20
1
2024
entrez:
19
1
2024
Statut:
epublish
Résumé
Although some studies have shown neuroimaging and neuropsychological alterations in post-COVID-19 patients, fewer combined neuroimaging and neuropsychology evaluations of individuals who presented a mild acute infection. Here we investigated cognitive dysfunction and brain changes in a group of mildly infected individuals. We conducted a cross-sectional study of 97 consecutive subjects (median age of 41 years) without current or history of psychiatric symptoms (including anxiety and depression) after a mild infection, with a median of 79 days (and mean of 97 days) after diagnosis of COVID-19. We performed semi-structured interviews, neurological examinations, 3T-MRI scans, and neuropsychological assessments. For MRI analyses, we included a group of non-infected 77 controls. The MRI study included white matter (WM) investigation with diffusion tensor images (DTI) and functional connectivity with resting-state functional MRI (RS-fMRI). The patients reported memory loss (36%), fatigue (31%) and headache (29%). The quantitative analyses confirmed symptoms of fatigue (83% of participants), excessive somnolence (35%), impaired phonemic verbal fluency (21%), impaired verbal categorical fluency (13%) and impaired logical memory immediate recall (16%). The WM analyses with DTI revealed higher axial diffusivity values in post-infected patients compared to controls. Compared to controls, there were no significant differences in the functional connectivity of the posterior cingulum cortex. There were no significant correlations between neuropsychological scores and neuroimaging features (including DTI and RS-fMRI). Our results suggest persistent cognitive impairment and subtle white matter abnormalities in individuals mildly infected without anxiety or depression symptoms. The longitudinal analyses will clarify whether these alterations are temporary or permanent.
Identifiants
pubmed: 38242927
doi: 10.1038/s41598-024-52005-7
pii: 10.1038/s41598-024-52005-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1758Subventions
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 88887.505625/2020-00
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2021/09230-5
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2019/11457-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2020/04032-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2019/233160
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2013/03557-9
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil
ID : 403307/2021-0
Informations de copyright
© 2024. The Author(s).
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