Reproducibility of 3D pH-weighted chemical exchange saturation transfer contrast in the healthy cervical spinal cord.
CEST MRI
pH-weighted contrast
postprocessing corrections
reproducibility
Journal
NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233
Informations de publication
Date de publication:
19 Jan 2024
19 Jan 2024
Historique:
revised:
01
12
2023
received:
07
08
2023
accepted:
20
12
2023
medline:
20
1
2024
pubmed:
20
1
2024
entrez:
20
1
2024
Statut:
aheadofprint
Résumé
Spinal cord ischemia and hypoxia can be caused by compression, injury, and vascular alterations. Measuring ischemia and hypoxia directly in the spinal cord noninvasively remains challenging. Ischemia and hypoxia alter tissue pH, providing a physiologic parameter that may be more directly related to tissue viability. Chemical exchange saturation transfer (CEST) is an MRI contrast mechanism that can be made sensitive to pH. More specifically, amine/amide concentration independent detection (AACID) is a recently developed endogenous CEST contrast that has demonstrated sensitivity to intracellular pH at 9.4 T. The goal of this study was to evaluate the reproducibility of AACID CEST measurements at different levels of the healthy cervical spinal cord at 3.0 T incorporating B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
Organisme : NSERC Discovery Grant
ID : RGPIN/05290-2020
Organisme : Canada First Research Excellence Fund
Organisme : NSERC Canada Graduate Scholarships Doctoral (CGS-D) Program
Informations de copyright
© 2024 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.
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