Patterns of executive functions and theory of mind in adults with a family history of alcohol use disorder: Combined group and single-case analyses.
alcohol use disorder
executive functions
family history
social cognition
theory of mind
Journal
Alcohol, clinical & experimental research
ISSN: 2993-7175
Titre abrégé: Alcohol Clin Exp Res (Hoboken)
Pays: United States
ID NLM: 9918609780906676
Informations de publication
Date de publication:
20 Jan 2024
20 Jan 2024
Historique:
revised:
24
11
2023
received:
03
07
2023
accepted:
26
11
2023
medline:
20
1
2024
pubmed:
20
1
2024
entrez:
20
1
2024
Statut:
aheadofprint
Résumé
Impairments in executive function and social cognition are highly prevalent in individuals with an alcohol use disorder (AUD). Some studies show that similar difficulties are displayed by individuals with a positive family history of AUD (FH+) compared with individuals with a negative family history (FH-). Yet, no studies have jointly investigated cognitive and affective theory of mind at the behavioral level. Moreover, some studies show preserved executive and socioemotional functioning in FH+ participants. One possible explanation for these divergent results is that FH+ individuals are cognitively heterogeneous. In this study, we examined the frequency and co-occurrence of difficulties in executive function and social cognition among FH+ individuals at the individual level. Sixty FH+ and 60 FH- participants matched on age, sex, and education level were included. They completed tasks assessing executive functions (Stroop, Trail Making Test) and affective and cognitive theory of mind (Movie for the Assessment of Social Cognition). They also completed self-report questionnaires measuring impulsivity, alexithymia, and empathy. Single-case analyses assessed the proportion of FH+ participants with difficulties in executive function and/or theory of mind. FH+ individuals exhibited difficulties in response inhibition and made more errors during theory of mind processing, indicating an absence of mental state representation, compared with FH- individuals. In the FH+ sample, 53.33% had executive function and/or theory of mind difficulties. Those with lower theory of mind scores reported higher alexithymia and lower empathy on self-report measures. FH+ individuals display heterogeneous executive function and theory of mind abilities. Given that they mostly occur independently of one another, executive function and theory of mind difficulties may be distinct vulnerability markers in AUD.
Sections du résumé
BACKGROUND
BACKGROUND
Impairments in executive function and social cognition are highly prevalent in individuals with an alcohol use disorder (AUD). Some studies show that similar difficulties are displayed by individuals with a positive family history of AUD (FH+) compared with individuals with a negative family history (FH-). Yet, no studies have jointly investigated cognitive and affective theory of mind at the behavioral level. Moreover, some studies show preserved executive and socioemotional functioning in FH+ participants. One possible explanation for these divergent results is that FH+ individuals are cognitively heterogeneous. In this study, we examined the frequency and co-occurrence of difficulties in executive function and social cognition among FH+ individuals at the individual level.
METHODS
METHODS
Sixty FH+ and 60 FH- participants matched on age, sex, and education level were included. They completed tasks assessing executive functions (Stroop, Trail Making Test) and affective and cognitive theory of mind (Movie for the Assessment of Social Cognition). They also completed self-report questionnaires measuring impulsivity, alexithymia, and empathy. Single-case analyses assessed the proportion of FH+ participants with difficulties in executive function and/or theory of mind.
RESULTS
RESULTS
FH+ individuals exhibited difficulties in response inhibition and made more errors during theory of mind processing, indicating an absence of mental state representation, compared with FH- individuals. In the FH+ sample, 53.33% had executive function and/or theory of mind difficulties. Those with lower theory of mind scores reported higher alexithymia and lower empathy on self-report measures.
CONCLUSIONS
CONCLUSIONS
FH+ individuals display heterogeneous executive function and theory of mind abilities. Given that they mostly occur independently of one another, executive function and theory of mind difficulties may be distinct vulnerability markers in AUD.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Université de Reims Champagne-Ardenne
Organisme : University Hospital Reims
ID : PHU N-DevX
Informations de copyright
© 2023 The Authors. Alcohol: Clinical and Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol.
Références
Abu-Akel, A. & Shamay-Tsoory, S. (2011) Neuroanatomical and neurochemical bases of theory of mind. Neuropsychologia, 49, 2971-2984.
Acheson, A., Tagamets, M.A., Rowland, L.M., Mathias, C.W., Wright, S.N., Hong, L.E. et al. (2014) Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task. Alcoholism, Clinical and Experimental Research, 38, 2944-2951.
American Psychiatric Association (Ed.). (2013) Diagnostic and statistical manual of mental disorders, 5th edition. Washington, DC: American Psychiatric Association.
Amico, E., Dzemidzic, M., Oberlin, B.G., Carron, C.R., Harezlak, J., Goñi, J. et al. (2020) The disengaging brain: dynamic transitions from cognitive engagement and alcoholism risk. NeuroImage, 209, 116515.
Apperly, I.A., Samson, D. & Humphreys, G.W. (2005) Domain-specificity and theory of mind: evaluating neuropsychological evidence. Trends in Cognitive Sciences, 9, 572-577.
Billieux, J., Rochat, L., Ceschi, G., Carré, A., Offerlin-Meyer, I., Defeldre, A.-C. et al. (2012) Validation of a short French version of the UPPS-P impulsive behavior scale. Comprehensive Psychiatry, 53, 609-615.
Bora, E. & Zorlu, N. (2017) Social cognition in alcohol use disorder: a meta-analysis. Addiction, 112, 40-48.
Cassel, A., McDonald, S., Kelly, M. & Togher, L. (2019) Learning from the minds of others: a review of social cognition treatments and their relevance to traumatic brain injury. Neuropsychological Rehabilitation, 29, 22-55.
Collet, L. & Cottraux, J. (1986) Inventaire abrégé de la dépression de Beck (13 items): Étude de la validité concurrente avec les échelles de Hamilton et de ralentissement de Widlöcher. L'Encephale Revue de Psychiatrie Clinique Biologique et Therapeutique, 12, 77-79.
Cox, S., Bertoux, M., Turner, J.J.D., Moss, A., Locker, K. & Riggs, K. (2018) Aspects of alcohol use disorder affecting social cognition as assessed using the Mini Social and Emotional Assessment (mini-SEA). Drug and Alcohol Dependence, 187, 165-170.
Crawford, J.R. & Garthwaite, P.H. (2005) Testing for suspected impairments and dissociations in single-case studies in neuropsychology: evaluation of alternatives using Monte Carlo simulations and revised tests for dissociations. Neuropsychology, 19, 318-331.
Crawford, J.R. & Howell, D.C. (1998) Comparing an individual's test score against norms derived from small samples. The Clinical Neuropsychologist, 12, 482-486.
Cservenka, A. (2016) Neurobiological phenotypes associated with a family history of alcoholism. Drug and Alcohol Dependence, 158, 8-21.
Dang, J., King, K.M. & Inzlicht, M. (2020) Why are self-report and behavioral measures weakly correlated? Trends in Cognitive Sciences, 24, 267-269.
Dawson, D.A. (2000) The link between family history and early onset alcoholism: earlier initiation of drinking or more rapid development of dependence? Journal of Studies on Alcohol, 61, 637-646.
DeVito, E.E., Meda, S.A., Jiantonio, R., Potenza, M.N., Krystal, J.H. & Pearlson, G.D. (2013) Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. Neuropsychopharmacology, 38, 1854-1863.
Dougherty, D.M., Lake, S.L., Mathias, C.W., Ryan, S.R., Bray, B.C., Charles, N.E. et al. (2015) Behavioral impulsivity and risk-taking trajectories across early adolescence in youths with and without family histories of alcohol and other drug use disorders. Alcoholism, Clinical and Experimental Research, 39, 1501-1509.
Dziobek, I., Fleck, S., Kalbe, E., Rogers, K., Hassenstab, J., Brand, M. et al. (2006) Introducing MASC: a movie for the assessment of social cognition. Journal of Autism and Developmental Disorders, 36, 623-636.
Elton, A., Allen, J.H., Yorke, M., Khan, F., Xu, P. & Boettiger, C.A. (2023) Sex moderates family history of alcohol use disorder and childhood maltreatment effects on an fMRI stop-signal task. Human Brain Mapping, 44(6), 2436-2450.
Etchepare, A. & Prouteau, A. (2018) Toward a two-dimensional model of social cognition in clinical neuropsychology: a systematic review of factor structure studies. Journal of the International Neuropsychological Society, 24, 391-404.
Filippi, I., Hoertel, N., Artiges, E., Airagnes, G., Guérin-Langlois, C., Seigneurie, A.-S. et al. (2019) Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives. European Psychiatry, 62, 107-115.
Gache, P., Michaud, P., Landry, U., Accietto, C., Arfaoui, S., Wenger, O. et al. (2005) The alcohol use disorders identification test (AUDIT) as a screening tool for excessive drinking in primary care: reliability and validity of a French version. Alcoholism, Clinical and Experimental Research, 29, 2001-2007.
Gierski, F., Hubsch, B., Stefaniak, N., Benzerouk, F., Cuervo-Lombard, C., Bera-Potelle, C. et al. (2013) Executive functions in adult offspring of alcohol-dependent probands: toward a cognitive endophenotype? Alcoholism, Clinical and Experimental Research, 37, E356-E363.
Gilet, A.-L., Mella, N., Studer, J., Grühn, D. & Labouvie-Vief, G. (2013) Assessing dispositional empathy in adults: a French validation of the interpersonal reactivity index (IRI). Canadian Journal of Behavioural Science/Revue Canadienne des Sciences du Comportement, 45, 42-48.
Golden, C.J. (1978) The Stroop color and word test: a manual for clinical and experimental uses. Chicago, IL: Stoelting Company Edition.
Grainger, S.A., Crawford, J.D., Riches, J.C., Kochan, N.A., Chander, R.J., Mather, K.A. et al. (2023) Aging is associated with multidirectional changes in social cognition: findings from an adult life-span sample ranging from 18 to 101 years. The Journals of Gerontology: Series B, 78, 62-72.
Grynberg, D., Maurage, P. & Nandrino, J.-L. (2017) Preserved affective sharing but impaired decoding of contextual complex emotions in alcohol dependence. Alcoholism, Clinical and Experimental Research, 41, 779-785.
Guinle, M.I.B., & Sinha, R. (2020) The role of stress, trauma, and negative affect in the development of alcohol misuse and alcohol use disorders in women. Alcohol Research: Current Reviews, 40. Available from: https://doi.org/10.35946/arcr.v40.2.05
Ham, L.S., Zamboanga, B.L., Bacon, A.K. & Garcia, T.A. (2009) Drinking motives as mediators of social anxiety and hazardous drinking among college students. Cognitive Behaviour Therapy, 38, 133-145.
Hardee, J.E., Weiland, B.J., Nichols, T.E., Welsh, R.C., Soules, M.E., Steinberg, D.B. et al. (2014) Development of impulse control circuitry in children of alcoholics. Biological Psychiatry, 76, 708-716.
Heatherton, T.F., Kozlowski, L.T., Frecker, R.C. & Fagerström, K.O. (1991) The Fagerström test for nicotine dependence: a revision of the Fagerström tolerance questionnaire. British Journal of Addiction, 86, 1119-1127.
Henderson, K.E., Vaidya, J.G., Kramer, J.R., Kuperman, S., Langbehn, D.R. & O'Leary, D.S. (2018) Cortical thickness in adolescents with a family history of alcohol use disorder. Alcoholism, Clinical and Experimental Research, 42, 89-99.
Hill, S.Y., Kostelnik, B., Holmes, B., Goradia, D., McDermott, M., Diwadkar, V. et al. (2007) fMRI BOLD response to the eyes task in offspring from multiplex alcohol dependence families. Alcoholism, Clinical and Experimental Research, 31, 2028-2035.
Jenkins, M.B., Agrawal, A., Lynskey, M.T., Nelson, E.C., Madden, P.A.F., Bucholz, K.K. et al. (2011) Correlates of alcohol abuse/dependence in early-onset alcohol-using women. The American Journal on Addictions, 20, 429-434.
Khemiri, L., Franck, J. & Jayaram-Lindström, N. (2022) Effect of alcohol use disorder family history on cognitive function. Psychological Medicine, 52, 757-769.
Kirk-Provencher, K.T., Penner, A.E., McRae, K. & Gowin, J.L. (2023) Emotion regulation in young adults with family history of harmful alcohol use: a fMRI study. Drug and Alcohol Dependence, 243, 109752.
Kosty, D.B., Farmer, R.F., Seeley, J.R., Merikangas, K.R., Klein, D.N., Gau, J.M. et al. (2020) The number of biological parents with alcohol use disorder histories and risk to offspring through age 30. Addictive Behaviors, 102, 106196.
Kumar, L., Hill, S.Y. & Creswell, K.G. (2023) Social cognition and problematic alcohol use: an organizing theoretical framework and suggestions for future work. In: Federmeier, K.D. & Montag, J.L. (Eds.) Psychology of learning and motivation. Cambridge, MA: Elsevier.
Kumar, L., Skrzynski, C.J. & Creswell, K.G. (2022) Systematic review and meta-analysis on the association between theory of mind and alcohol problems in non-clinical samples. Alcoholism, Clinical and Experimental Research, 46, 1944-1952.
Lees, B., Aguinaldo, L., Squeglia, L.M., Infante, M.A., Wade, N.E., Hernandez Mejia, M. et al. (2020) Parental family history of alcohol use disorder and neural correlates of response inhibition in children from the adolescent brain cognitive development (ABCD) study. Alcoholism, Clinical and Experimental Research, 44, 1234-1244.
Long, E.C., Lönn, S.L., Ji, J., Lichtenstein, P., Sundquist, J., Sundquist, K. et al. (2017) Resilience and risk for alcohol use disorders: a Swedish twin study. Alcoholism, Clinical and Experimental Research, 41, 149-155.
Lovallo, W.R., Yechiam, E., Sorocco, K.H., Vincent, A.S. & Collins, F.L. (2006) Working memory and decision-making biases in young adults with a family history of alcoholism: studies from the Oklahoma family health patterns project. Alcoholism, Clinical and Experimental Research, 30, 763-773.
Mackinnon, A. & Mulligan, R. (2005) Estimation de l'intelligence prémorbide chez les francophones. L'Encéphale, 31, 31-43.
Mannuzza, S., Fyer, A., Endicott, J. & Klein, D.F. (1985) Family informant schedule and criteria (FISC). New York, NY: New York State Psychiatric Institute, New York Anxiety Disorders Clinic.
Maurage, F., de Timary, P., Tecco, J.M., Lechantre, S. & Samson, D. (2015) Theory of mind difficulties in patients with alcohol dependence: beyond the prefrontal cortex dysfunction hypothesis. Alcoholism, Clinical and Experimental Research, 39, 980-988.
Maurage, P., Pabst, A., Lannoy, S., D'Hondt, F., de Timary, P., Gaudelus, B. et al. (2021) Tackling heterogeneity: individual variability of emotion decoding deficits in severe alcohol use disorder. Journal of Affective Disorders, 279, 299-307.
Miyake, A., Friedman, N.P., Emerson, M.J., Witzki, A.H., Howerter, A. & Wager, T.D. (2000) The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cognitive Psychology, 41, 49-100.
Nickels, L., Fischer-Baum, S. & Best, W. (2022) Single case studies are a powerful tool for developing, testing and extending theories. Nature Reviews Psychology, 1, 733-747.
Pabst, A., Gautier, M. & Maurage, P. (2022) Tasks and investigated components in social cognition research among adults with alcohol use disorder: a critical scoping review. Psychology of Addictive Behaviors, 36, 999-1011.
Pandey, G., Seay, M.J., Meyers, J.L., Chorlian, D.B., Pandey, A.K., Kamarajan, C. et al. (2020) Density and dichotomous family history measures of alcohol use disorder as predictors of behavioral and neural phenotypes: a comparative study across gender and race/ethnicity. Alcoholism, Clinical and Experimental Research, 44, 697-710.
Paquette, D., Laporte, L., Bigras, M. & Zoccolillo, M. (2004) Validation de la version française du CTQ et prévalence de l'histoire de maltraitance 1. Santé Mentale au Québec, 29, 201-220.
Pitel, A.L., Beaunieux, H., Witkowski, T., Vabret, F., Guillery-Girard, B., Quinette, P. et al. (2007) Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence. Alcoholism, Clinical and Experimental Research, 31, 1169-1178.
Pitel, A.L., Rivier, J., Beaunieux, H., Vabret, F., Desgranges, B. & Eustache, F. (2009) Changes in the episodic memory and executive functions of abstinent and relapsed alcoholics over a 6-month period. Alcoholism, Clinical and Experimental Research, 33, 490-498.
Quaglino, V., De Wever, E. & Maurage, P. (2015) Relations between cognitive abilities, drinking characteristics, and emotional recognition in alcohol dependence: a preliminary exploration. Alcoholism, Clinical and Experimental Research, 39, 2032-2038.
Rehm, J. & Shield, K.D. (2019) Global burden of disease and the impact of mental and addictive disorders. Current Psychiatry Reports, 21, 10.
Reitan, R.M. (1958) Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271-276.
Roye, S., Calamia, M. & Robinson, A. (2022) Examining patterns of executive functioning across dimensions of psychopathology. Journal of Behavior Therapy and Experimental Psychiatry, 77, 101778.
Schmid, F., Benzerouk, F., Barrière, S., Henry, A., Limosin, F., Kaladjian, A. et al. (2021) Heterogeneity of executive function abilities in recently detoxified patients with alcohol use disorder: evidence from a cluster analysis. Alcoholism, Clinical and Experimental Research, 45, 163-173.
Schmid, F., Henry, A., Benzerouk, F., Barrière, S., Portefaix, C., Gondrexon, J. et al. (2023) Neural activations during cognitive and affective theory of mind processing in healthy adults with a family history of alcohol use disorder. Psychological Medicine, 1-11.
Schmid, F., Moreau, F., Benzerouk, F., Raucher-Chéné, D., Kaladjian, A., Gierski, F. et al. (2022) Faux pas recognition and executive processes in patients with alcohol use disorder: toward an investigation of Interindividual heterogeneity. Archives of Clinical Neuropsychology, 37, 608-620.
Schmidt, T., Roser, P., Ze, O., Juckel, G., Suchan, B. & Thoma, P. (2017) Cortical thickness and trait empathy in patients and people at high risk for alcohol use disorders. Psychopharmacology, 234, 3521-3533.
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E. et al. (1998) The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. The Journal of Clinical Psychiatry, 59(Suppl 20), 22-57.
Silveri, M.M., Rogowska, J., McCaffrey, A. & Yurgelun-Todd, D.A. (2011) Adolescents at risk for alcohol abuse demonstrate altered frontal lobe activation during Stroop performance. Alcoholism, Clinical and Experimental Research, 35, 218-228.
Snyder, H.R., Miyake, A. & Hankin, B.L. (2015) Advancing understanding of executive function impairments and psychopathology: bridging the gap between clinical and cognitive approaches. Frontiers in Psychology, 6, 328.
Spielberger, C.D., Goruch, R.L., Lushene, R.E., Vagg, P.R. & Jacobs, G.A. (1983) Manual for the state-trait inventory STAI (form Y). Palo Alto, CA: Mind Gard.
Stephan, R.A., Alhassoon, O.M., Allen, K.E., Wollman, S.C., Hall, M., Thomas, W.J. et al. (2017) Meta-analyses of clinical neuropsychological tests of executive dysfunction and impulsivity in alcohol use disorder. The American Journal of Drug and Alcohol Abuse, 43, 24-43.
Wilcox, C.E., Dekonenko, C.J., Mayer, A.R., Bogenschutz, M.P. & Turner, J.A. (2014) Cognitive control in alcohol use disorder: deficits and clinical relevance. Reviews in the Neurosciences, 25, 1-24.
Xin, F. & Lei, X. (2015) Competition between frontoparietal control and default networks supports social working memory and empathy. Social Cognitive and Affective Neuroscience, 10, 1144-1152.
Zech, E., Luminet, O., Rimé, B. & Wagner, H. (1999) Alexithymia and its measurement: confirmatory factor analyses of the 20-item Toronto alexithymia scale and the Bermond-Vorst alexithymia questionnaire. European Journal of Personality, 13, 511-532.